1-(1-Chloro-2,2-difluoroethyl)benzene CAS 345-62-0
| CAS No. | 345-62-0 |
| Molecular Formula | C8H7ClF2 |
| Molecular Weight | 176.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C8H7ClF2, 1-(1-Chloro-2,2-difluoroethyl)benzene contains fluorine/chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 176.59 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
1-(1-Chloro-2,2-difluoroethyl)benzene (CAS 345-62-0), molecular formula C8H7ClF2 and molecular weight 176.59 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H7ClF2 |
| Molecular Weight | 176.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 1-Chloro-3-(1,1-difluoroethyl)benzene (CAS 1204295-57-7)
- 1-Chloro-2-(1,1-difluoroethyl)benzene (CAS 1204295-71-5)
- 3-Chloro-2-(difluoromethyl)toluene (CAS 1261555-24-1)
- 2-Chloro-4-(difluoromethyl)-1-methylbenzene (CAS 1261567-84-3)
- 2-Chloro-1-(difluoromethyl)-3-methylbenzene (CAS 1261584-51-3)
- 4-Chloro-2-(difluoromethyl)-1-methylbenzene (CAS 1261648-11-6)
- 1-Chloro-4-(difluoromethyl)-2-methylbenzene (CAS 1261673-29-3)
- 5-Chloro-2-(difluoromethyl)toluene (CAS 1261729-10-5)
Recommended Standards
- (2-Chloro-1,1-difluoroethyl)benzene (CAS 55805-08-8)
- 1-Chloro-4-(1,1-difluoroethyl)benzene (CAS 55805-04-4)
- 1-Chloro-2-fluoro-3-(fluoromethyl)-4-methylbenzene (CAS 1805502-26-4)
- 2-(2-Chloroethyl)-1,3-difluorobenzene (CAS 959232-39-4)
- 57742-41-3 Benzyl chloride-|A-13C |A-Chlorotoluene-|A-13C (CAS 57742-41-3)
- (4-((2-Hydroxyethyl)carbamoyl)phenyl)boronic acid (CAS 850593-04-3)
- 1-Ethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole (CAS 1607838-36-7)
- 2-[3-(difluoromethyl)-5-methyl-1h-pyrazol-1-yl]propanehydrazide (CAS 1005631-76-4)
- 1,1'-(Ethane-1,2-diylbis(4,1-phenylene))bis(ethan-1-one) (CAS 793-06-6)
- 5-Ethynyl-2-methyl-3-nitropyridine (CAS 1228962-70-6)
- Methyl 5-fluoro-1H-benzimidazole-4-carboxylate (CAS 1193789-41-1)
- 3-tert-Butyl-1-(3,5-Dichlorophenyl)-1H-pyrazol-5-amine (CAS 1017781-15-5)
- 4-(Piperidin-4-ylmethyl)benzamide (CAS 333795-12-3)
- Semaglutide impurity 96 (CAS CATO-C4X-222696)
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