Bis(4-chlorophenyl)ethanedione CAS 3457-46-3
| CAS No. | 3457-46-3 |
| Molecular Formula | C14H8Cl2O2 |
| Molecular Weight | 279.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Bis(4-chlorophenyl)ethanedione is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Bis(4-chlorophenyl)ethanedione (CAS 3457-46-3) is a high-purity analytical reference standard with the molecular formula C14H8Cl2O2 and a molecular weight of 279.12 g/mol.
The molecular framework of Bis(4-chlorophenyl)ethanedione (C14H8Cl2O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures Bis(4-chlorophenyl)ethanedione under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H8Cl2O2 |
| Molecular Weight | 279.12 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
Related Bis Standards
- 1-(2-Chlorophenyl)-3-(3-chlorophenyl)propan-1-one (CAS 898787-22-9)
- 1-(2-Chlorophenyl)-3-(4-chlorophenyl)propan-1-one (CAS 898788-21-1)
- 1-(3-Chlorophenyl)-3-(4-chlorophenyl)propan-1-one (CAS 898787-88-7)
- 1,3-Bis(4-chlorophenyl)propan-1-one (CAS 97009-36-4)
- 3-(3-Chlorophenyl)-1-(4-chlorophenyl)propan-1-one (CAS 898762-62-4)
- 3-(3-Chlorophenyl)-1,4-diazaspiro[4.5]dec-3-ene-2-thione (CAS 1325304-96-8)
- (3-Chlorophenyl)(4-(ethylthio)phenyl)methanol (CAS 844683-56-3)
- (4-Chlorophenyl)(4-(ethylthio)phenyl)methanol (CAS 844683-43-8)
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- Silverneodecanoate (CAS 68683-18-1)
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- GS 4898 (CAS 41255-30-5)
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- Des-Tyr10-Tirzepatide (CAS CATO-CPTD788680)
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