Ethyl 4-chloro-2-(pyridin-3-yl)pyrimidine-5-carboxylate CAS 34775-04-7
| CAS No. | 34775-04-7 |
| Molecular Formula | C12H10ClN3O2 |
| Molecular Weight | 263.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Ethyl 4-chloro-2-(pyridin-3-yl)pyrimidine-5-carboxylate (CAS 34775-04-7) is a high-purity analytical reference standard with the molecular formula C12H10ClN3O2 and a molecular weight of 263.68 g/mol.
The molecular framework of Ethyl 4-chloro-2-(pyridin-3-yl)pyrimidine-5-carboxylate (C12H10ClN3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Ethyl 4-chloro-2-(pyridin-3-yl)pyrimidine-5-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H10ClN3O2 |
| Molecular Weight | 263.68 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Ethyl Standards
- 4-Chloro-1-(2,2-diethoxyethyl)-3-nitro-1h-pyrazole (CAS 1006951-79-6)
- 1-Benzyl-5-chloro-2-oxo-1,2-dihydro-3-pyridinecarboxylic acid (CAS 101384-62-7)
- 4-Chloro-3-methoxy-6-phenylpicolinic acid (CAS 1019930-14-3)
- Ethyl 4-chloro-2-(pyridin-2-yl)pyrimidine-5-carboxylate (CAS 1044770-41-3)
- 2-chloro-N-[(5-methylfuran-2-yl)methyl]-7H-purin-6-amine (CAS 1133758-66-3)
- 4-Chloro-6-ethyl-2-(4-nitrophenyl)pyrimidine (CAS 1153297-96-1)
- Ethyl 6-chloro-2-(pyridin-2-yl)pyrimidine-4-carboxylate (CAS 1240597-44-7)
- 5-(3-Chloro-4-methoxyphenyl)nicotinic acid (CAS 1261960-17-1)
Recommended Standards
- 6-amino-5-(2-chloroacetyl)-1-(2-methoxyethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione (CAS 941117-65-3)
- Ethyl 4-chloro-2-(pyridin-4-yl)pyrimidine-5-carboxylate (CAS 204394-36-5)
- 6-(5-Chloro-2-methoxyphenyl)picolinic acid (CAS 376592-08-4)
- Methyl 1-(4-chlorobenzoyl)-1H-pyrrole-2-carboxylate (CAS 866154-29-2)
- 5-(Benzyloxy)pyridine-2-carboxylic acid (CAS 74386-55-3)
- 2-Chloro-4-(piperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine (CAS 1070165-92-2)
- (4-methylcyclohexyl)(2-methylphenyl)methanone (CAS 1249300-05-7)
- 4-(((3-Methylthiophen-2-yl)methylene)amino)-3-(pyridin-2-yl)-1H-1,2,4-triazole-5(4H)-thione (CAS 613248-17-2)
- (S)-3-(2,2-difluoroethyl)pyrrolidine hydrochloride (CAS 2708342-85-0)
- Tert-butyl (2-methyl-3-(2-methyl-1,3-dioxolan-2-yl)propyl)carbamate (CAS 1354962-70-1)
- 4-Ethylphenyl trans-4-(4-n-pentylcyclohexyl)benzoate (CAS 91223-44-8)
- 1-(1H,1'H-[2,5'-Bibenzo[d]imidazol]-2'-yl)ethanol (CAS 519017-28-8)
- [2-(2-Methoxyphenoxy)-3-pyridinyl]methanamine (CAS 953728-49-9)
- Liraglutide(10-22)TFA Salt (CAS CATO-C4X-199211)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com