5-Chloro-2,4-difluoroaniline CAS 348-65-2
| CAS No. | 348-65-2 |
| Molecular Formula | C6H4ClF2N |
| Molecular Weight | 163.55 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-Chloro-2,4-difluoroaniline is closely related to a nitrile group, fluorine/chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 5-Chloro-2,4-difluoroaniline (CAS 348-65-2), a certified reference material (molecular formula C6H4ClF2N, MW 163.55 g/mol) for analytical method development and quality control.
5-Chloro-2,4-difluoroaniline (C6H4ClF2N) contains a nitrile group, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H4ClF2N |
| Molecular Weight | 163.55 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 2-Chloro-6-(difluoromethyl)pyridine (CAS 1026587-36-9)
- 4-Chloro-2-(difluoromethyl)pyridine (CAS 1193104-11-8)
- 3-Chloro-5-(difluoromethyl)pyridine (CAS 1335055-92-9)
- 6-Chloro-2,3-difluoroaniline (CAS 1373920-77-4)
- 5-Chloro-2-(difluoromethyl)pyridine (CAS 1374659-32-1)
- 3-Chloro-4-(difluoromethyl)pyridine (CAS 1374659-44-5)
- 4-Chloro-3,5-difluoro-2-methylpyridine (CAS 139161-94-7)
- 3-Chloro-4,5-difluoroaniline (CAS 149144-05-8)
Recommended Standards
- 5-Chloro-2,3-difluoroaniline (CAS 870606-45-4)
- 6-Chloropyridine-3,4-dicarbonitrile (CAS 1166799-46-7)
- 4-Chloro-3,5-difluoroaniline (CAS 2613-33-4)
- 2-Chloropyridine-3,5-dicarbonitrile (CAS 172208-08-1)
- 1-Methyl-1-propylpiperidinium Bis(fluorosulfonyl)imide (CAS 911303-46-3)
- 7-Hydroxybenzothiazole-2-carboxylic acid (CAS 1261578-77-1)
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- 3-Cyclohexyl-D-alanyl-D-α-glutamylglycine-d11 (CAS 1356011-66-9)
- Brexpiprazole Impurity 61 (CAS CATO-C4X-113161)
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- Avatrombopag Impurity 73 (CAS CATO-C4X-223473)
- 1-Chloro-1,1,5,5,5-pentafluoro-2,4-pentanedione, tech (CAS 203302-89-0)
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