4-(Trifluoromethyl)phenyl carbonochloridate CAS 34857-66-4
| CAS No. | 34857-66-4 |
| Molecular Formula | C8H4ClF3O2 |
| Molecular Weight | 224.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-(Trifluoromethyl)phenyl carbonochloridate (CAS 34857-66-4) is a high-purity analytical reference standard with the molecular formula C8H4ClF3O2 and a molecular weight of 224.56 g/mol.
The molecular framework of 4-(Trifluoromethyl)phenyl carbonochloridate (C8H4ClF3O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-(Trifluoromethyl)phenyl carbonochloridate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H4ClF3O2 |
| Molecular Weight | 224.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Halogen Content | F/Cl-containing |
Related Trifluoromethyl Standards
- 2-(Trifluoromethyl)phenyl carbonochloridate (CAS 869676-40-4)
- 3-(Trifluoromethyl)phenyl Chloroformate (CAS 95668-29-4)
- 4-(4-(Trifluoromethyl)piperidin-1-yl)butan-1-amine (CAS 1416351-97-7)
- 2-(4-(Trifluoromethyl)thiazol-2-yl)butan-2-amine (CAS 1249000-84-7)
- N-((2-(trifluoromethyl)thiazol-4-yl)methyl)propan-2-amine (CAS 1420993-20-9)
- 1-[6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]methanamine (CAS 889943-45-7)
- 4-methyl-6-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridin-3-amine (CAS 832740-69-9)
- 2-(4-(Trifluoromethyl)cyclohexyl)propanoic acid (CAS 1513213-56-3)
Recommended Standards
- 4-(Trifluoromethoxy)benzoyl Chloride (CAS 36823-88-8)
- 4-Chloro-2,3,6-trifluorophenylacetic acid (CAS 537033-63-9)
- 3-Chloro-5-(trifluoromethyl)benzoic Acid (CAS 53985-49-2)
- 4-Chloro-3-(difluoromethyl)-2-fluorobenzoic acid (CAS 2386446-01-9)
- 2-Hydroxy-3-methylhexanoic acid (CAS 89794-94-5)
- 6-(Methoxycarbonyl)-1H-pyrrolo[3,2-b]pyridine-3-carboxylic acid (CAS 1190315-00-4)
- Potassium 2-carboxy-4,6-diiodophenolate (CAS 1015937-56-0)
- 2-Chloro-3-fluorobenzenethiol (CAS 1208076-56-5)
- (E)-4-(2,6-dichlorostyryl)-8-phenoxy-2,3-dihydrothieno[3,2-c]quinoline (CAS 866018-48-6)
- Methyl (2-cyanoethyl)glycinate (CAS 44915-39-1)
- (S)-2-chloro-7-methyl-9-(tetrahydrofuran-3-yl)-7,9-dihydro-8H-purin-8-one (CAS 2230820-59-2)
- 4-Bromo-2-methyl-6-(trifluoromethoxy)quinoline (CAS 1189107-42-3)
- Belumosudil Impurity 60 (CAS CATO-C4X-298860)
- Insulin Degludec Impurity 6 (CAS CATO-C4X-21576)
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