N-(2,4-Difluorophenyl)-2-(thiophen-2-yl)acetamide CAS 349432-67-3

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-(2,4-Difluorophenyl)-2-(thiophen-2-yl)acetamide.

CATO supplies N-(2,4-Difluorophenyl)-2-(thiophen-2-yl)acetamide (CAS 349432-67-3), a certified reference material (molecular formula C12H9F2NOS, MW 253.27 g/mol) for analytical method development and quality control.

The molecular framework of N-(2,4-Difluorophenyl)-2-(thiophen-2-yl)acetamide (C12H9F2NOS) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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