9,9-Bis(3,4-dihydroxyphenyl)fluorene CAS 351521-78-3

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 9,9-Bis(3,4-dihydroxyphenyl)fluorene.

9,9-Bis(3,4-dihydroxyphenyl)fluorene (CAS 351521-78-3), molecular formula C25H18O4 and molecular weight 382.41 g/mol, is a CATO reference standard with documented purity and traceability.

Structurally, 9,9-Bis(3,4-dihydroxyphenyl)fluorene (C25H18O4) contains a flavonoid core, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 17.0, corresponding to approximately 17 ring(s) or double-bond equivalent(s). With a molecular weight of 382.41 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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