1-(3-Chlorophenyl)-3-(4H-1,2,4-triazol-4-yl)urea CAS 35224-67-0

Purity 97%+In StockPharmaceutical Standards
CAS No.35224-67-0
Molecular FormulaC9H8ClN5O
Molecular Weight237.65 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

1-(3-Chlorophenyl)-3-(4H-1,2,4-triazol-4-yl)urea CAS 35224-67-0 chemical structure

Description

1-(3-Chlorophenyl)-3-(4H-1,2,4-triazol-4-yl)urea (CAS 35224-67-0) is a high-purity analytical reference standard with the molecular formula C9H8ClN5O and a molecular weight of 237.65 g/mol.

The molecular framework of 1-(3-Chlorophenyl)-3-(4H-1,2,4-triazol-4-yl)urea (C9H8ClN5O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC9H8ClN5O
Molecular Weight237.65 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor)
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)8.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1967
Halogen ContentCl-containing
Nitrogen Atoms5

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