Tenofovir Disoproxil Impurity 45 CAS 35273-90-6
| CAS No. | 35273-90-6 |
| Molecular Formula | C5H9ClO3 |
| Molecular Weight | 152.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tenofovir Disoproxil Impurity 45.
Tenofovir Disoproxil Impurity 45 (CAS 35273-90-6) is a certified pharmaceutical impurity reference standard with the molecular formula C5H9ClO3 and a molecular weight of 152.58 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, Tenofovir Disoproxil Impurity 45 is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 152.58 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Tenofovir Disoproxil Impurity 45 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H9ClO3 |
| Molecular Weight | 152.58 g/mol |
| Purity | >90% |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | Cl-containing |
Related Tenofovir Standards
- Tenofovir disoproxil Impurity 96 (CAS 35180-01-9)
- Tenofovir Impurity 165 (CAS 80549-03-7)
- Tenofovir Impurity 166 (CAS 262423-81-4)
- Tenofovir Impurity 88 (CAS 1681-15-8)
- Tenofovir disoproxil Impurity 39 (CAS 87-42-3)
- Tenofovir Impurity 115 (CAS 155102-96-8)
- Tenofovir disoproxil Impurity 136 (CAS CATO-C4X-1076136)
- Tenofovir Impurity 144 (CAS 2715-68-6)
Recommended Standards
- 6-Chloro-1H-indazole (CAS 698-25-9)
- 66909-36-2 6-Chloro-2-methylpyridine-3-carbonitrile DTXSID80495839 (CAS 66909-36-2)
- N-Nitroso Trazodone Impurity 45 (CAS CATO-C4X-177245)
- N-(3-Chlorophenyl)-cyanamide (CAS 54507-99-2)
- Vinblastine impurity 9 (CAS CATO-C4X-19849)
- Oxazepam impurity 02 (CAS 4015-28-5)
- Suvorexant Impurity 34 (CAS CATO-C4X-181234)
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- 1-[(2,4-difluorophenyl)methyl]-5-methyl-1H-1,2,3-triazol-4-amine hydrochloride (CAS 1803590-61-5)
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- 2,4-TDI-bis-1,2MP (CAS 190653-33-9)
- Ethyl 2-chloro-4-(1H-pyrazol-1-yl)benzoate (CAS 1956355-90-0)
- (S)-2,2'-Dibromo-1,1'-binaphthalene (CAS 150024-49-0)
- Insulin Degludec Impurity 1 (CAS 843666-26-2)
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