5-(3-Chloro-2-methylphenyl)furan-2-carboxylic acid CAS 353761-03-2
| CAS No. | 353761-03-2 |
| Molecular Formula | C12H9ClO3 |
| Molecular Weight | 236.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-(3-Chloro-2-methylphenyl)furan-2-carboxylic acid.
CATO supplies 5-(3-Chloro-2-methylphenyl)furan-2-carboxylic acid (CAS 353761-03-2), a certified reference material (molecular formula C12H9ClO3, MW 236.65 g/mol) for analytical method development and quality control.
5-(3-Chloro-2-methylphenyl)furan-2-carboxylic acid (C12H9ClO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H9ClO3 |
| Molecular Weight | 236.65 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
Related Chloro Standards
- 3-((4-Chloro-1H-pyrazol-1-yl)methoxy)benzaldehyde (CAS 1006460-35-0)
- 4-Chloro-6-(3-methoxyphenoxy)pyrimidine (CAS 1017087-53-4)
- 2-Chloro-5-(1-methyl-1H-pyrazol-3-yl)benzoic acid (CAS 1031418-17-3)
- 5-Chloro-n-(4-methylpyridin-2-yl)furan-2-carboxamide (CAS 1043110-13-9)
- 5-(4-Chloro-3-methylphenoxy)furan-2-carbaldehyde (CAS 1082167-98-3)
- 5-(2-Chloro-5-methoxyphenyl)pyrimidin-2-ol (CAS 1111104-23-4)
- 5-(5-Chloro-2-methoxyphenyl)pyrimidin-2-ol (CAS 1111104-25-6)
- 5-(3-Chloro-4-methoxyphenyl)pyrimidin-2-ol (CAS 1111108-41-8)
Recommended Standards
- 5-(2-Chlorophenyl)-2-methylfuran-3-carboxylic acid (CAS 4414-49-7)
- 5-(3-Chloro-4-methylphenyl)furan-2-carboxylic acid (CAS 378218-08-7)
- 5-(2-Chlorophenoxymethyl)furan-2-carbaldehyde (CAS 438220-35-0)
- 5-(3-Chlorobenzyl)-1H-pyrazole-3-carboxylic acid (CAS 595610-55-2)
- 4-((((1-Ethyl-1H-pyrazol-5-yl)methyl)amino)methyl)-2-methoxyphenol hydrochloride (CAS 1856059-56-7)
- 1-Boc-piperidin-4-ylpropionicacid 154375-43-6 4-(2-Carboxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester A3393 (CAS 154375-43-6)
- H-D-Cys-OH · HCl · H2O (CAS 207121-46-8)
- 1,3-dimethyl-1H,4H,5H,6H-pyrazolo[3,4-b][1,4]thiazine (CAS 1354952-12-7)
- 6-Tosyl-1-oxa-6-azaspiro[3.3]Heptan-3-ol (CAS 1349199-64-9)
- 3-Amino-2-(thiophen-2-yl)propan-1-ol (CAS 1368786-10-0)
- 3-(2-Chlorophenoxy)benzaldehyde (CAS 72178-85-9)
- 1-((2R,3S,4S,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-5-(fluoromethyl)-3-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (CAS 196604-62-3)
- 2-(4-Methylpiperazin-1-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazine (CAS 1186042-00-1)
- Semaglutide Impurity 189 (CAS CATO-C4X-2226189)
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