6-Amino-4-(pyridin-3-yl)-3-(trifluoromethyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile CAS 353762-21-7
| CAS No. | 353762-21-7 |
| Molecular Formula | C13H8F3N5O |
| Molecular Weight | 307.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
6-Amino-4-(pyridin-3-yl)-3-(trifluoromethyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile (CAS 353762-21-7), molecular formula C13H8F3N5O and molecular weight 307.23 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 6-Amino-4-(pyridin-3-yl)-3-(trifluoromethyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile (C13H8F3N5O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), 6-Amino-4-(pyridin-3-yl)-3-(trifluoromethyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H8F3N5O |
| Molecular Weight | 307.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Amino Standards
- Ethyl {[2-[amino(hydroxyimino)methyl]-5-(trifluoromethyl)pyridin-3-yl]oxy}acetate (CAS 1993797-83-3)
- 279228-81-8 3-amino-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide DTXSID70434297 (CAS 279228-81-8)
- Ethyl (3-amino-5-nitro-1H-indazole-1-carbonyl)(methyl)carbamate (CAS 65288-55-3)
- 3-(2-Amino-4-bromophenoxy)-N,N-dimethylaniline (CAS 946665-07-2)
- 6-Amino-N-phenyl-[1,3]dioxolo[4,5-g]quinoline-7-carboxamide (CAS 131336-38-4)
- 2-Amino-4,6-bis(4-fluorophenyl)nicotinonitrile (CAS 171254-52-7)
- 2-(Boc-amino)-4-bromo-5-formylthiazole (CAS 944805-17-8)
- 4-Amino-7-fluoro-2-(2-oxo-6-thioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione (CAS 2858759-42-7)
Recommended Standards
- 5-Phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (CAS 312635-16-8)
- 6-Nitro-1-(4-(trifluoromethyl)phenyl)-1H-indazole (CAS 838820-86-3)
- 5-Phenyl-7-(trifluoromethyl)pyrazolo-[1,5-a]pyrimidine-2-carboxylic acid (CAS 294194-47-1)
- 7-(Difluoromethyl)-5-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (CAS 712319-09-0)
- 2-((3-Cyano-6-phenyl-4-(p-tolyl)pyridin-2-yl)thio)-N-(2-methyl-4-nitrophenyl)acetamide (CAS 332128-06-0)
- Ethyl Adenosine-5'-carboxylate Hydrochloride (CAS 50663-70-2)
- 1-(2,6-Difluorophenyl)-3-((1-((2,5-dimethylfuran-3-yl)methyl)piperidin-4-yl)methyl)urea (CAS 1235319-01-3)
- (2-(Trifluoromethoxy)phenyl)hydrazine (CAS 791029-98-6)
- (1R,2R)-2-(Diphenylphosphanyl)-2,3-dihydro-1H-inden-1-amine tetrafluoroborate salt (CAS 1222630-69-4)
- 4-benzyl-3-chloro-5-phenyl-4H-1,2,4-triazole (CAS 1020043-28-0)
- Benzyl2,3-o-isopropylidene-6-o-trityl-5-keto-alpha-d-mannofuranose (CAS 91364-12-4)
- 3-[(1Z)-1-[2-(6-Chloropyridin-2-yl)hydrazin-1-yl]-2-(1H-1,2,4-triazol-1-yl)ethylidene]-1-phenylurea (CAS 338418-61-4)
- 2-Iodo-3-Nitrobenzyl bromide (CAS 1261777-67-6)
- Semaglutide Impurity 8 (CAS CATO-C4X-22268)
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