4,6,7-Trichloro-2-(pyrimidin-2-ylamino)-2,3-dihydrobenzofuran-5-ol CAS 354552-50-4
| CAS No. | 354552-50-4 |
| Molecular Formula | C12H8Cl3N3O2 |
| Molecular Weight | 332.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 4,6,7-Trichloro-2-(pyrimidin-2-ylamino)-2,3-dihydrobenzofuran-5-ol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
4,6,7-Trichloro-2-(pyrimidin-2-ylamino)-2,3-dihydrobenzofuran-5-ol (CAS 354552-50-4), molecular formula C12H8Cl3N3O2 and molecular weight 332.57 g/mol, is a CATO reference standard with documented purity and traceability.
4,6,7-Trichloro-2-(pyrimidin-2-ylamino)-2,3-dihydrobenzofuran-5-ol (C12H8Cl3N3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C12H8Cl3N3O2 |
| Molecular Weight | 332.57 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Trichloro Standards
- 2,4,6-Trichloro-N-(3-methoxyphenyl)pyrimidine-5-carboxamide (CAS 87847-99-2)
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- Trichloro(3,3,4,4,5,5,5-heptafluoropentyl)silane (CAS 866-24-0)
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- 2,2,2-Trichloro-1-(4-(2-methylbenzoyl)-1H-pyrrol-2-yl)ethan-1-one (CAS 338403-92-2)
- 2,2,2-Trichloro-1-(4-(2-phenylacetyl)-1H-pyrrol-2-yl)ethan-1-one (CAS 338394-85-7)
Recommended Standards
- 3-(Methyl(2,5,6-trichloropyrimidin-4-yl)amino)benzoic acid (CAS 6372-19-6)
- 5-Chloro-1-(2,4-dichlorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid (CAS 338977-77-8)
- 5-Chloro-1-(2,4-dichlorobenzyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid (CAS 242797-47-3)
- 1-[1-(2H-1,3-Benzodioxol-5-yl)-1H-pyrrol-2-yl]-2,2,2-trichloroethan-1-one (CAS 383147-46-4)
- Dapoxetine nitrogen oxide mixture (5 = 5) (CAS CATO-C3D-1265-2)
- (S)-1-PHENYLBUT-3-EN-1-AMINE HCL (CAS 130887-64-8)
- 0450AD 1185301-94-3 C6H15ClN2O3S [4-(Methylsulfonyl)morpholin-2-yl]methylamine hydrochloride (CAS 1185301-94-3)
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- 4-(4-Isobutoxyphenyl)-1H-pyrazole (CAS 1394023-27-8)
- 3-[benzyl(4-methoxyphenyl)sulfamoyl]benzoic acid (CAS 750610-53-8)
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