5-Methyl-3-(trifluoromethyl)isoxazole-4-carboxylic acid CAS 354795-48-5
| CAS No. | 354795-48-5 |
| Molecular Formula | C6H4F3NO3 |
| Molecular Weight | 195.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 195.10 g/mol gives 5-Methyl-3-(trifluoromethyl)isoxazole-4-carboxylic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies 5-Methyl-3-(trifluoromethyl)isoxazole-4-carboxylic acid (CAS 354795-48-5), a certified reference material (molecular formula C6H4F3NO3, MW 195.10 g/mol) for analytical method development and quality control.
Structurally, 5-Methyl-3-(trifluoromethyl)isoxazole-4-carboxylic acid (C6H4F3NO3) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 195.10 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Methyl-3-(trifluoromethyl)isoxazole-4-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H4F3NO3 |
| Molecular Weight | 195.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Methyl Standards
- 1-Methyl-5-(trifluoromethyl)-1H-1,2,3-triazole-4-carboxylic Acid (CAS 1266841-66-0)
- 4-Methyl-2-(trifluoromethyl)oxazole-5-carboxylic acid (CAS 1384265-64-8)
- 1-Methyl-4-(trifluoromethyl)-1H-1,2,3-triazole-5-carboxylic acid (CAS 1393540-74-3)
- methyl 2-(trifluoromethyl)-1,3-oxazole-5-carboxylate (CAS 1803603-75-9)
- 2-Methyl-5-(trifluoromethyl)oxazole-4-carboxylic acid (CAS 18955-88-9)
- 3-Methyl-5-trifluoromethyl-isoxazole-4-carboxylic acid (CAS 193952-09-9)
- 2-methyl-4-(trifluoromethyl)-1,3-oxazole-5-carboxylic acid (CAS 499766-90-4)
- 2-Methyl-5-(trifluoromethyl)-2H-1,2,3-triazole-4-carboxylic acid (CAS 668491-30-3)
Recommended Standards
- 5-Bromo-2,2-dimethylpentan-1-ol (CAS 411217-72-6)
- 5-Methyl-4-nitro-3-(trifluoromethyl)-1H-pyrazole (CAS 1998157-92-8)
- 4-Nitro-1-(2,2,2-trifluoroethyl)-1h-pyrazole (CAS 919278-38-9)
- 5-Methyl-4-nitro-3-(trifluoromethyl)-1H-pyrazole (CAS 27116-80-9)
- 1-(4-Pyridyl)cyclopropanamine Dihydrochloride (CAS 1228880-35-0)
- 1-(Difluoromethyl)-3-nitro-1H-1,2,4-triazole (CAS 2137653-18-8)
- (2-(Aminomethyl)pyridin-3-yl)methanol dihydrochloride (CAS 1159812-22-2)
- 6-(4-Chlorophenyl)-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-5-one (CAS 861206-07-7)
- 1-Cyclohexylpyrimidine-2,4,6-trione (CAS 1015-65-2)
- 2-Iodo-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid (CAS 1638768-78-1)
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