4-(O-tolyloxy)benzoicacid CAS 355154-50-6
| CAS No. | 355154-50-6 |
| Molecular Formula | C14H12O3 |
| Molecular Weight | 228.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(O-tolyloxy)benzoicacid.
4-(O-tolyloxy)benzoicacid (CAS 355154-50-6), molecular formula C14H12O3 and molecular weight 228.24 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system, 4-(O-tolyloxy)benzoicacid is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 228.24 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-(O-tolyloxy)benzoicacid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H12O3 |
| Molecular Weight | 228.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
Related O Standards
- 3-(O-tolyloxy)benzoicacid (CAS 135611-26-6)
- 2-(M-tolyloxy)benzoic acid (CAS 6338-04-1)
- 2-(O-tolyloxy)benzoicacid (CAS 6325-68-4)
- 4-(m-Tolyloxy)benzoic acid (CAS 62507-85-1)
- 4-(P-tolyloxy)benzoicacid (CAS 21120-65-0)
- (4-(P-tolyloxy)phenyl)boronic acid (CAS 1029438-40-1)
- (2-(p-Tolyloxy)phenyl)boronic acid (CAS 1412761-94-4)
- 2-(o-Tolyloxy)nicotinic acid (CAS 117570-87-3)
Recommended Standards
- 4-(Naphthalen-1-yl)-4-oxobutanoic Acid (CAS 4653-13-8)
- 4-(Phenoxymethyl)benzoic Acid (CAS 31719-76-3)
- 4'-(Hydroxymethyl)biphenyl-3-carboxylic acid (CAS 773872-69-8)
- 4-Benzyloxy-3-hydroxybenzaldehyde, 97% (CAS 4049-39-2)
- Ethyl-2,2,2-d3-triphenylphosphonium Bromide (CAS 1560-55-0)
- 2,4-Dibromo-3-chloro-6-ethoxyaniline (CAS 1706444-61-2)
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