N-(4,5-Difluoro-2-hydroxyphenyl)acetamide CAS 356557-98-7
| CAS No. | 356557-98-7 |
| Molecular Formula | C8H7F2NO2 |
| Molecular Weight | 187.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 187.14 g/mol gives N-(4,5-Difluoro-2-hydroxyphenyl)acetamide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
N-(4,5-Difluoro-2-hydroxyphenyl)acetamide (CAS 356557-98-7), molecular formula C8H7F2NO2 and molecular weight 187.14 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, N-(4,5-Difluoro-2-hydroxyphenyl)acetamide is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 187.14 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H7F2NO2 |
| Molecular Weight | 187.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
- N-(2,3-Difluoro-6-Hydroxyphenyl)-Acetamide (CAS 941608-41-9)
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- Methyl 4-amino-2,5-difluorobenzoate (CAS 952285-52-8)
- N-{[4-(difluoromethoxy)phenyl]methylidene}hydroxylamine (CAS 556016-57-0)
- 6-Methoxy-benzo[d]isoxazole-3-carboxylic acid ethyl ester (CAS 57764-51-9)
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- 3-(Bicyclo[1.1.1]Pentan-1-yl)benzoic acid (CAS 1823902-30-2)
- 1-(1,3-Dihydroisobenzofuran-5-yl)-2,2,2-trifluoroethanone (CAS 1538172-82-5)
- (S)-1-(4-fluoro-2-(trifluoromethyl)phenyl)ethan-1-amine (CAS 1228569-90-1)
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- 3-(6-Chlorobenzo[d]thiazol-2-yl)-1-(2,4-dichlorobenzyl)pyridin-2(1H)-one (CAS 400075-86-7)
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- 3-isothiocyanato-2,3-dihydro-1$l^{6}-thiophene-1,1-dione (CAS 893725-07-0)
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