Naloxone Hydrochloride CAS 357-08-4
| CAS No. | 357-08-4 |
| Molecular Formula | C19H21NO4 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Naloxone Hydrochloride (CAS 357-08-4) is a high-purity analytical reference standard with the molecular formula C19H21NO4HCl and a molecular weight of 363.84 g/mol.
Naloxone Hydrochloride (C19H21NO4HCl) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Naloxone Hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H21NO4 HCl |
| Molecular Weight | 363.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Naloxone Standards
- Naloxone Impurity 21 (CAS 119630-94-3)
- Naloxone-D5 (CAS 1261079-38-2)
- Naloxone-d5 3-Methyl Ether (1.0mg/ml in Acetonitrile) (CAS 1261082-21-6)
- Naloxone Hydrochloride EP Impurity B (CAS 1352085-46-1)
- Naloxone-d5 HCl (CAS 1426174-78-8)
- Naloxone Impurity 18 (CAS 156047-22-2)
- Naloxone Hydrochloride EP Impurity E (CAS 211738-08-8)
- Naloxone Hydrochloride EP Impurity C (CAS 2139253-68-0)
Recommended Standards
- 2,4-Di-tert-butyl-6-chlorophenol (CAS 4166-86-3)
- 3-Bromo-5-cyclopropoxyisonicotinamide (CAS 1243383-50-7)
- Ethyl 2-((1-methoxypropan-2-yl)amino)-4-methylthiazole-5-carboxylate (CAS 949265-73-0)
- 2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrazine (CAS 1220526-75-9)
- (2,5-Difluorophenyl)(6-methoxypyridin-2-yl)methanone (CAS 1187170-59-7)
- 5-Bromo-N-methoxyfuran-3-carboxamide (CAS 1090046-35-7)
- 2,3-Difluoro-5-methylbenzoic acid (CAS 1003709-96-3)
- 2-(Diethylamino)-1,3-thiazole-5-carbaldehyde (CAS 92940-24-4)
- Besudil Impurity 14 (CAS CATO-C4X-298814)
- Serpent Peptide (CAS 823202-99-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
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