1-(4-Fluorobenzyl)piperidin-4-amine dihydrochloride CAS 358748-22-8
| CAS No. | 358748-22-8 |
| Molecular Formula | C12H17FN2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 1-(4-Fluorobenzyl)piperidin-4-amine dihydrochloride (C12H17FN2HCl) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
1-(4-Fluorobenzyl)piperidin-4-amine dihydrochloride (CAS 358748-22-8) is a high-purity analytical reference standard with the molecular formula C12H17FN2HCl and a molecular weight of 244.74 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H17FN2 2*HCl |
| Molecular Weight | 244.74 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Fluorobenzyl Standards
- (4-Fluorobenzyl)hydrazine dihydrochloride (CAS 1000805-93-5)
- (3-Fluorobenzyl)hydrazine Dihydrochloride (CAS 1000805-94-6)
- 5-((3-Fluorobenzyl)oxy)-1H-pyrazol-3-amine (CAS 1000896-51-4)
- 4-(5-(4-Fluorobenzyl)-1H-pyrazol-3-yl)pyridine (CAS 1001112-68-0)
- 2-(5-(4-Fluorobenzyl)-3-(pyridin-4-yl)-4,5-dihydro-1H-pyrazol-1-yl)acetic acid (CAS 1001383-88-5)
- 3-(4-Fluorobenzyl)pyrrolidinehydrochloride (CAS 1003561-95-2)
- 1-(4-Fluorobenzyl)-4-isothiocyanato-3,5-dimethyl-1h-pyrazole (CAS 1004193-64-9)
- 4-((4-Fluorobenzyl)amino)-1-methyl-1H-pyrazole-3-carboxylic acid (CAS 1006448-78-7)
Recommended Standards
- 5-Isobutylpyrazin-2-amine (CAS 59489-76-8)
- 2-(((4-Fluorophenyl)thio)methyl)pyrrolidine hydrochloride (CAS 1353989-69-1)
- (2,3-Diaza-4-(2-methoxyphenyl)-1-methylthiobuta-1,3-dienyl)prop-2-enylamine, hydroiodide (CAS 1274948-46-7)
- 1-((1H-benzo[d]imidazol-1-yl)methyl)cyclopentan-1-ol (CAS 1488932-81-5)
- MDM2 inhibitor (CAS 562823-84-1)
- 2-((1S,2S)-2-aminocyclohexyl)isoindoline-1,3-dione (CAS 1240398-42-8)
- 3-Methoxy-4-({[2-(trifluoromethyl)phenyl]carbamoyl}methoxy)benzoic acid (CAS 522624-57-3)
- 4,4-Difluoro-1-glycylpyrrolidine-2-carbonitrile (CAS 1823820-60-5)
- 6-Chloro-2,1,3-benzoselenadiazole (CAS 6343-86-8)
- Semaglutide impurity 258 (CAS CATO-C4X-2226258)
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