Clomipramine EP Impurity D CAS 3589-22-8
| CAS No. | 3589-22-8 |
| Molecular Formula | C19H22Cl2N2 |
| Molecular Weight | 349.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Clomipramine EP Impurity D (CAS 3589-22-8, C19H22Cl2N2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Clomipramine EP Impurity D (C19H22Cl2N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Clomipramine EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H22Cl2N2 |
| Molecular Weight | 349.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Clomipramine Standards
- Clomipramine RC 1 (CAS 223787-55-1)
- Clomipramine-d6 N-Oxide (CAS 1189479-06-8)
- Clomipramine N-Oxide (CAS 14171-67-6)
- Clomipramine Impurity 13 (CAS 79752-04-8)
- Clomipramine-D3 (CAS 136765-29-2)
- Clomipramine (CAS 303-49-1)
- Clomipramine EP Impurity C (CAS 2095-42-3)
- Clomipramine Impurity 9 (CAS CATO-C4X-12659)
Recommended Standards
- Ethyl 5-hydroxy-3-(4-methoxyphenyl)-2-methyl-5-(trifluoromethyl)-1,2-oxazolidine-4-carboxylate (CAS 321391-89-3)
- N*1*-(6-Morpholin-4-yl-3-nitro-4-trifluoromethyl-pyridin-2-yl)-propane-1,3-diamine (CAS 1089330-47-1)
- Ethyl 4-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxylate (CAS 954125-17-8)
- (3R,4R,5S,6S)-3-acetamido-6-(fluoromethyl)tetrahydro-2H-pyran-2,4,5-triyl triacetate (CAS 1094213-88-3)
- Iopromide impurity 13 (CAS CATO-C4X-183213)
- Nintedanib Impurity 169 (CAS CATO-C4X-1814169)
- Ipragliflozin Impurity 3 (CAS CATO-C4X-18853)
- 2-(3-Methyl-piperidine-1-sulfonyl)-ethylamineoxalate (CAS 1185299-66-4)
- 4-Cyanophenyl hydroxycarbamimidate (CAS 651306-31-9)
- Ethyl 3,4-dihydro-2H-1,4-benzoxazine-2-carboxylate (CAS 22244-22-0)
- Tirzepatide Impurity 48 (CAS CATO-C4X-324048)
- Methyl 1-(difluoromethyl)-1H-imidazole-5-carboxylate (CAS 2350052-23-0)
- n-(Furan-2-ylmethyl)-2-hydroxy-n-methylacetamide (CAS 926235-09-8)
- Semaglutide Impurity 188 (CAS CATO-C4X-2226188)
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