Methyl 3-Amino-2,6-difluorophenylacetate CAS 361336-80-3
| CAS No. | 361336-80-3 |
| Molecular Formula | C9H9F2NO2 |
| Molecular Weight | 201.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Methyl 3-Amino-2,6-difluorophenylacetate is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Methyl 3-Amino-2,6-difluorophenylacetate (CAS 361336-80-3) is a high-purity analytical reference standard with the molecular formula C9H9F2NO2 and a molecular weight of 201.17 g/mol.
The molecular framework of Methyl 3-Amino-2,6-difluorophenylacetate (C9H9F2NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), Methyl 3-Amino-2,6-difluorophenylacetate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H9F2NO2 |
| Molecular Weight | 201.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Methyl Standards
- 2-Amino-2-(2,6-difluorophenyl)propanoic acid (CAS 1134330-97-4)
- 2-amino-2-(2,5-difluorophenyl)propanoic acid (CAS 1134619-17-2)
- Ethyl 2-amino-4,6-difluorobenzoate (CAS 1147107-15-0)
- 2-Amino-2-(3,4-difluorophenyl)propanoic acid (CAS 1152858-59-7)
- Ethyl 5-amino-2,4-difluorobenzoate (CAS 1159507-72-8)
- 2-Amino-1-(3-(difluoromethoxy)phenyl)ethan-1-one (CAS 1178024-70-8)
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Recommended Standards
- Methyl 3-Amino-2,6-difluorobenzoate (CAS 84832-02-0)
- Methyl 4-amino-2,5-difluoro-3-methylbenzoate (CAS 208166-53-4)
- Methyl 2-amino-2-(3,4-difluorophenyl)acetate (CAS 218449-31-1)
- N-(2-(difluoromethoxy)phenyl)acetamide (CAS 22236-05-1)
- (R)-2-(4-chloro-3-(difluoromethyl)-2-fluorophenyl)pyrrolidine (CAS 1447108-01-1)
- Pcb No. 122 (CAS 76842-07-4)
- 4-Amino-5-cyclopropyl-1-methyl-2-phenyl-2,3-dihydro-1h-pyrazol-3-one (CAS 856847-31-9)
- Bendamustine USP Related Compound G (CAS 191939-34-1)
- 5-(4-Ethylphenyl)oxazole-2-carboxylic acid (CAS 1216272-66-0)
- tert-butyl 4-amino-3-formyl-1H-indole-1-carboxylate 1195784-87-2 A1-00545 (CAS 1195784-87-2)
- 2-(3-Chloro-4-nitrophenyl)-4-phenylcyclohexan-1-one (CAS 1980086-54-1)
- 3-(pyrrolidin-3-yl)-4H-1,2,4-triazole hydrochloride (CAS 1909337-56-9)
- n,n-Diethyl-4-iodobenzenesulfonamide (CAS 167156-20-9)
- Tirzepatide Impurity 44 (CAS CATO-C4X-324044)
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