3-[[(2S)-1-Methyl-2-pyrrolidinyl]methyl]-5-[(1E)-2-(phenylsulfonyl)ethenyl]-1H-indole CAS 362595-66-2
| CAS No. | 362595-66-2 |
| Molecular Formula | C22H24N2O2S |
| Molecular Weight | 380.50 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-[[(2S)-1-Methyl-2-pyrrolidinyl]methyl]-5-[(1E)-2-(phenylsulfonyl)ethenyl]-1H-indole is closely related to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3-[[(2S)-1-Methyl-2-pyrrolidinyl]methyl]-5-[(1E)-2-(phenylsulfonyl)ethenyl]-1H-indole (CAS 362595-66-2), molecular formula C22H24N2O2S and molecular weight 380.50 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-[[(2S)-1-Methyl-2-pyrrolidinyl]methyl]-5-[(1E)-2-(phenylsulfonyl)ethenyl]-1H-indole (C22H24N2O2S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H24N2O2S |
| Molecular Weight | 380.50 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Recommended Standards
- 3-(Hexadecyloxy)propyl dihydrogen phosphate (CAS 87746-71-2)
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- 2-(Dicyclohexylphosphino)-2'-methoxy-1,1'-biphenyl (CAS 255835-82-6)
- 4-tert-Butylphenyl 5-(1,2,3-thiadiazol-4-yl)thiophene-2-sulfonate (CAS 338400-14-9)
- 2-(4-Bromo-2-chlorophenyl)-2,2-difluoroacetic acid (CAS 1823816-46-1)
- 5,5-dimethylpyrrolidin-2-imine hydrochloride (CAS 179684-58-3)
- (E)-3-Allylhex-4-enamide (CAS 110397-00-7)
- Tadalafil Impurity 61 (CAS 1370438-57-5)
- 5-Ethynylpicolinamide (CAS 1314640-56-6)
- 2-{[(2-chloro-6-fluorophenyl)methyl]sulfanyl}-4-(4-methylphenyl)-1H,4H,5H-indeno[1,2-d]pyrimidin-5-one (CAS 691873-09-3)
- 3-(3,4-dichlorophenyl)aniline (CAS 926201-88-9)
- (2-Chloro-5-fluoropyrimidin-4-yl)-(3-trifluoromethylphenyl)amine (CAS 575473-62-0)
- 9-Nitrophenanthrene (CAS 954-46-1)
- Liraglutide Impurity 21 TFA Salt (CAS CATO-C4X-199221)
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