Ethyl 2-chloro-4,4,4-trifluoroacetoacetate CAS 363-58-6
| CAS No. | 363-58-6 |
| Molecular Formula | C6H6ClF3O3 |
| Molecular Weight | 218.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Ethyl 2-chloro-4,4,4-trifluoroacetoacetate (CAS 363-58-6), molecular formula C6H6ClF3O3 and molecular weight 218.56 g/mol, is a CATO reference standard with documented purity and traceability.
Ethyl 2-chloro-4,4,4-trifluoroacetoacetate (C6H6ClF3O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures Ethyl 2-chloro-4,4,4-trifluoroacetoacetate under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H6ClF3O3 |
| Molecular Weight | 218.56 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
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Recommended Standards
- [(1R)-1-chlorocarbonyl-2,2,2-trifluoro-1-methyl-ethyl] acetate (CAS 2738609-12-4)
- 2-Chloro-3,6-difluorocinnamic acid (CAS 1163255-65-9)
- (E)-3-(4-chloro-3,5-difluorophenyl)acrylic acid (CAS 1163258-83-0)
- (E)-3-(5-Chloro-2,4-difluorophenyl)acrylic acid (CAS 2307843-32-7)
- Bariumrhodizonate (CAS 16833-52-6)
- Benzyl 3-(2-oxopyrrolidin-1-yl)azetidine-1-carboxylate (CAS 2385606-93-7)
- Ethyl2-guanidino-4-methylthiazole-5-carboxylate (CAS 7185-65-1)
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- Cefprozil EP Impurity C(Cefadroxil EP Impurity E) (CAS 147103-93-3)
- Peptide Impurity 40 (CAS CATO-CPTD788840)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com