2-(2,4-Difluorophenyl)-4-fluorobenzo[d][1,3,2]dioxaborole CAS 365458-32-8

Purity 97%+In StockPharmaceutical Standards
CAS No.365458-32-8
Molecular FormulaC12H6BF3O2
Molecular Weight249.98 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

2-(2,4-Difluorophenyl)-4-fluorobenzo[d][1,3,2]dioxaborole CAS 365458-32-8 chemical structure

Description

Structurally, 2-(2,4-Difluorophenyl)-4-fluorobenzo[d][1,3,2]dioxaborole (C12H6BF3O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 8.5, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 249.98 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

2-(2,4-Difluorophenyl)-4-fluorobenzo[d][1,3,2]dioxaborole (CAS 365458-32-8), molecular formula C12H6BF3O2 and molecular weight 249.98 g/mol, is a CATO reference standard with documented purity and traceability.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 2-(2,4-Difluorophenyl)-4-fluorobenzo[d][1,3,2]dioxaborole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC12H6BF3O2
Molecular Weight249.98 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in chloroform, dichloromethane, ethyl acetate, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)8.5
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)2025
Halogen ContentF-containing

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