4-Chloro-2-ethyl-1-nitrobenzene CAS 36680-46-3
| CAS No. | 36680-46-3 |
| Molecular Formula | C8H8ClNO2 |
| Molecular Weight | 185.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-Chloro-2-ethyl-1-nitrobenzene is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 4-Chloro-2-ethyl-1-nitrobenzene (CAS 36680-46-3), a certified reference material (molecular formula C8H8ClNO2, MW 185.61 g/mol) for analytical method development and quality control.
The molecular framework of 4-Chloro-2-ethyl-1-nitrobenzene (C8H8ClNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8ClNO2 |
| Molecular Weight | 185.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
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Recommended Standards
- 4-Chloro-2,6-dimethylnicotinic acid (CAS 56022-09-4)
- 4-chloro-2-methoxybenzamide (CAS 89978-92-7)
- 4-Chloro-2-(methylamino)benzoic acid (CAS 54675-18-2)
- 4-Chloro-3,5-dimethylpicolinic Acid (CAS 447461-22-5)
- 1-Ethyl-3-methyl-1H-pyrazole (CAS 30433-57-9)
- N-Methoxy-2-((4-methoxybenzyl)oxy)-N-methylacetamide (CAS 191731-32-5)
- 3-Methoxy-L-phenylalanine (CAS 33879-32-2)
- 1-((4-Fluorophenyl)sulfonyl)-1,2,3,4-tetrahydroquinolin-7-amine (CAS 927996-70-1)
- bromo-N-[(bromomethyl)sulphonyl]-N-[3-(trifluoromethyl)phenyl]methanesulphonamide (CAS 286367-01-9)
- 4-bromo-1H-pyrrolo[2,3-b]pyridin-3-amine (CAS 943323-65-7)
- Nicotinic acid (3-amino-isoindol-1-ylidenE)-hydrazide (CAS 519152-72-8)
- Ethyl 2-bromo-5-cyano-4-iodobenzoate (CAS 1805579-70-7)
- n-(4-Amino-3-(trifluoromethyl)phenyl)cyclopropanecarboxamide (CAS 923125-43-3)
- Insulin Degludec Impurity 11 (CAS CATO-C4X-215711)
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