4-Chloro-2-picoline CAS 3678-63-5
| CAS No. | 3678-63-5 |
| Molecular Formula | C6H6ClN |
| Molecular Weight | 127.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Chloro-2-picoline (CAS 3678-63-5), molecular formula C6H6ClN and molecular weight 127.57 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-Chloro-2-picoline (C6H6ClN) is characterized by a nitrile group, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Chloro-2-picoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H6ClN |
| Molecular Weight | 127.57 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 4-Chloro-3-methylpyridine (CAS 1681-36-3)
- 2-Chloro-3-methylpyridine (CAS 18368-76-8)
- 3-Chloro-5-methylpyridine (CAS 19230-55-8)
- 3-Chloro-2-methylpyridine (CAS 72093-03-9)
- 3-Chloro-4-methylpyridine (CAS 72093-04-0)
- 5-Chloro-2-methylpyridine (CAS 72093-07-3)
- 2-Chloro-5-methylpyridine (CAS 18368-64-4)
- 4-Chloro-1H-imidazole-5-carbonitrile (CAS 1333380-68-9)
Recommended Standards
- Tellurium ICP Standard (CAS 13494-80-9)
- 4-Chloroaniline (CAS 106-47-8)
- (5-Methyl-1,2,4-oxadiazol-3-yl)boronic acid (CAS 1979125-36-4)
- Trazodone Impurity 13 (CAS 95-51-2)
- 3-Isopropyl-1-(propylthio)cyclobutane-1-carboxylic acid (CAS 1486993-10-5)
- Ac-Lys-AMC (CAS 156661-42-6)
- 2-Ethoxy-1H-benzo[d]imidazole-6-carbonitrile (CAS 952511-49-8)
- 4-Dimethylamino-1-naphthyl Isothiocyanate[for HPLC Labeling] (CAS 29711-79-3)
- 3-Trifluoromethylbenzyl isocyanide (CAS 602261-89-2)
- N-(2-methoxy-5-nitrophenyl)-2-((1-methyl-1H-tetrazol-5-yl)thio)acetamide (CAS 378225-56-0)
- 5-Bromo-2-chloro-4-fluorobenzonitrile (CAS 1892285-40-3)
- 5-Fluoro-3-(methoxymethyl)pyridin-2-amine (CAS 1097264-96-4)
- 2-(5-Oxobenzo[h]quinolin-6(5H)-ylidene)hydrazinecarboxamide (CAS 88346-09-2)
- Peptide Impurity 82 (CAS 10491-78-8)
Why CATO?
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