N-Butyl difluoroacetate CAS 368-35-4
| CAS No. | 368-35-4 |
| Molecular Formula | C6H10F2O2 |
| Molecular Weight | 152.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-Butyl difluoroacetate.
N-Butyl difluoroacetate (CAS 368-35-4) is a high-purity analytical reference standard with the molecular formula C6H10F2O2 and a molecular weight of 152.14 g/mol.
The molecular framework of N-Butyl difluoroacetate (C6H10F2O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H10F2O2 |
| Molecular Weight | 152.14 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Recommended Standards
- Ethyl 2,2-difluorobutanoate (CAS 2368-92-5)
- Phthalic-d4 Anhydride (CAS 75935-32-9)
- D-Ribose-5,5-d (CAS 478506-32-0)
- Ethyl 3,3-difluorobutanoate 3,3-Difluorobutyric acid ethyl ester 2368-93-6 (CAS 2368-93-6)
- n-(3-Chloro-4-fluorophenyl)-2-(4-formyl-2-methoxyphenoxy)acetamide (CAS 553628-53-8)
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- 2-(4-Chlorophenyl)-8-ethylquinoline-4-carboxylic acid (CAS 590350-43-9)
- 3-((3-Fluoro-4-methylphenyl)amino)-1-(3-nitrophenyl)propan-1-one (CAS 882748-49-4)
- 2,4-Dichloro-5-(methoxycarbonyl)phenyl pyrrolidine-1-carboxylate (CAS 133636-94-9)
- Copper bromo(triphenylphosphine)- (CAS 22176-37-0)
- 5-Methylisoquinoline-3-carboxylic acid (CAS 1781933-12-7)
- tert-butyl 2-allylazepane-1-carboxylate (CAS 153749-94-1)
- Semaglutide impurity 55 (CAS CATO-C4X-222655)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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