2-Methoxymethoxy-5-(trifluoromethyl)benzoic acid CAS 368422-27-9
| CAS No. | 368422-27-9 |
| Molecular Formula | C10H9F3O4 |
| Molecular Weight | 250.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-Methoxymethoxy-5-(trifluoromethyl)benzoic acid (CAS 368422-27-9) is a high-purity analytical reference standard with the molecular formula C10H9F3O4 and a molecular weight of 250.17 g/mol.
The molecular framework of 2-Methoxymethoxy-5-(trifluoromethyl)benzoic acid (C10H9F3O4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 2-Methoxymethoxy-5-(trifluoromethyl)benzoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H9F3O4 |
| Molecular Weight | 250.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
Related Methoxymethoxy Standards
- 2-(Methoxymethoxy)-4-(trifluoromethoxy)benzaldehyde (CAS 1321963-79-4)
- 2-(Methoxymethoxy)-3-(trifluoromethyl)benzoic acid (CAS 368422-26-8)
- 2-Methoxymethoxy-4-(trifluoromethyl)benzoic acid (CAS 368422-29-1)
- 7-(Methoxymethoxy)-2,2-dimethylchroman-6-carbaldehyde (CAS 2640655-31-6)
- (2-(Methoxymethoxy)-5-(trifluoromethyl)phenyl)boronic acid (CAS 1256355-54-0)
- 2-Methoxymethoxy-4-(trifluoromethyl)phenylboronic acid (CAS 659731-33-6)
- 2-(Methoxymethoxy)-6-methylbenzenesulfonyl chloride (CAS 2138186-74-8)
- 1-(Methoxymethoxy)-2-nitro-4-(trifluoromethyl)benzene (CAS 1881288-62-5)
Recommended Standards
- 2-Methyl-5,7-dinitroquinazolin-4(3H)-one (CAS 890092-86-1)
- 2-Ethoxy-5-(trifluoromethoxy)benzoic acid (CAS 773109-17-4)
- 3-(2-(Trifluoromethoxy)phenoxy)propanoic acid (CAS 276697-78-0)
- 2-Ethoxy-4-(trifluoromethoxy)benzoic acid (CAS 933063-50-4)
- 6-Chloro-3-(2-cyclopropylphenoxy)pyridazin-4-ol (CAS 499223-32-4)
- 2,3-Phenazinediol (CAS 19220-18-9)
- N-Acetyl Sulfapyridine (CAS 19077-98-6)
- 1-(2-Fluoro-5-(trifluoromethoxy)phenyl)ethan-1-one (CAS 1532864-35-9)
- (2-Chloro-5-(pyridin-4-yl)thiazol-4-yl)methanol (CAS 1935288-74-6)
- Bz-His-OMe (CAS 3005-62-7)
- 8-((5'-Amino-2'-Methyl-3'-Thiapentyl)Amino)-6-Methoxy-4-Methyl-5-((3-Trifluoromethyl)Phenoxy)Quinoline (CAS 98586-87-9)
- Sodium 2-(4-chlorobenzamido)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoate (CAS 169809-59-0)
- 6-Nitroquinoline-2-carbonitrile (CAS 13675-93-9)
- Tirzepatide Impurity 47 (CAS CATO-C4X-324047)
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