2-Amino-1-(4-fluorophenyl)ethan-1-one CAS 369-43-7
| CAS No. | 369-43-7 |
| Molecular Formula | C8H8FNO |
| Molecular Weight | 153.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-Amino-1-(4-fluorophenyl)ethan-1-one (CAS 369-43-7) is a high-purity analytical reference standard with the molecular formula C8H8FNO and a molecular weight of 153.15 g/mol.
2-Amino-1-(4-fluorophenyl)ethan-1-one (C8H8FNO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8FNO |
| Molecular Weight | 153.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Amino Standards
- 1-(4-Amino-2-fluorophenyl)ethan-1-one (CAS 112279-56-8)
- 1-(2-Amino-3-fluorophenyl)ethanone (CAS 124623-26-3)
- 1-(3-Amino-2-fluorophenyl)ethanone (CAS 1262098-06-5)
- 3-Amino-5-fluoro-2-methylbenzaldehyde (CAS 1378656-09-7)
- 1-(2-Amino-4-fluorophenyl)ethanone (CAS 159305-15-4)
- 1-(2-Amino-6-fluorophenyl)ethanone (CAS 869937-08-6)
- 1-(5-Amino-2-fluorophenyl)ethan-1-one (CAS 67500-19-0)
- 2’-Amino-5’-fluoroacetophenone (CAS 2343-25-1)
Recommended Standards
- 2-Amino-1-(3-fluorophenyl)ethan-1-one (CAS 792144-46-8)
- 2-Fluoro-4-methylbenzamide (CAS 886761-61-1)
- 2-Amino-1-(2-fluorophenyl)ethan-1-one (CAS 736887-62-0)
- 2-Fluoro-5-methylbenzamide (CAS 886500-04-5)
- 2-(Aminomethyl)-5-(difluoromethyl)-3,6-dihydroxypyridine (CAS 1806801-58-0)
- 2-Chloro-n-{[2-(trifluoromethoxy)phenyl]methyl}acetamide (CAS 949293-96-3)
- Fluorescent brightener er-iii (CAS 79026-03-2)
- [1-(4-chlorophenyl)cyclohexyl]methanamine (CAS 342425-45-0)
- (R)-5,6,7,8-Tetrahydro-isoquinolin-8-ylamine dihydrochloride (CAS 1965305-44-5)
- 3-((3,4-Dimethylphenyl)amino)-1-(thiophen-2-yl)propan-1-one (CAS 338988-74-2)
- Lusutrombopag Impurity 49 (CAS CATO-C4X-208449)
- 8-chloro-3-methyl-2,3,6,9-tetrahydro-1H-purine-2,6-dione (CAS 77350-93-7)
- 4-(1,3-Dioxaindan-5-yl)-3-methyl-1h-pyrazol-5-amine (CAS 1187767-29-8)
- Insulin Degludec Impurity 14 (CAS CATO-C4X-215714)
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