2-(3,4-Difluorophenoxy)acetic acid CAS 370-58-1
| CAS No. | 370-58-1 |
| Molecular Formula | C8H6F2O3 |
| Molecular Weight | 188.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 188.13 g/mol gives 2-(3,4-Difluorophenoxy)acetic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
2-(3,4-Difluorophenoxy)acetic acid (CAS 370-58-1) is a high-purity analytical reference standard with the molecular formula C8H6F2O3 and a molecular weight of 188.13 g/mol.
The molecular framework of 2-(3,4-Difluorophenoxy)acetic acid (C8H6F2O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-(3,4-Difluorophenoxy)acetic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H6F2O3 |
| Molecular Weight | 188.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Difluorophenoxy Standards
- (2,4-Difluorophenoxy)acetic acid (CAS 399-44-0)
- 2-(2,3-Difluorophenoxy)acetic acid (CAS 896052-06-5)
- 2-(2,5-Difluorophenoxy)acetic acid (CAS 366-56-3)
- 2-(2,6-Difluorophenoxy)acetic acid (CAS 363-45-1)
- 2-(3,5-Difluorophenoxy)acetic acid (CAS 370-02-5)
- 1-(3,5-Difluorophenoxy)propan-2-amine (CAS 1115027-28-5)
- 3-(3,5-Difluorophenoxy)propan-1-amine (CAS 1310243-42-5)
- 3-(2,3-Difluorophenoxy)propan-1-amine (CAS 1310246-61-7)
Recommended Standards
- 2-(2,6-Difluorophenyl)-2-hydroxyacetic acid (CAS 207981-50-8)
- 2-(Carboxymethyl)-5-oxotetrahydrofuran-2-carboxylic acid (CAS 91912-46-8)
- 2-(2,5-Difluorophenyl)-2-hydroxyacetic acid (CAS 207853-61-0)
- 2-(Difluoromethoxy)benzoic acid (CAS 97914-59-5)
- Benzo[d]oxazole-2-carboxylic acid, 97% (CAS 21598-08-3)
- 1-Ethynyl-8-methylnaphthalene (CAS 65265-94-3)
- rel-(2S,5R)-5-(((tert-butoxycarbonyl)amino)methyl)tetrahydrofuran-2-carboxylic acid (CAS 1807912-24-8)
- 4-Phenylhexan-3-one (CAS 6957-17-1)
- 1-Bromo-3-fluoro-2-(trifluoromethoxy)benzene (CAS 1242258-31-6)
- Clevidipine Butyrate impurity 19 (CAS 253597-20-5)
- Trelagliptin Impurity 21 (CAS 1821400-07-0)
- 1-Benzyl-2,3-dihydro-1H-indene (CAS 4831-01-0)
- Melphalan EP Impurity B DiHCl (CAS CATO-C4X-198820)
- Endo-Pro36-Tirzepatide (CAS CATO-CPTD788688)
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