1-(2-chlorophenyl)-3-methylenedihydro-1H-pyrrole-2,5-dione CAS 37010-60-9
| CAS No. | 37010-60-9 |
| Molecular Formula | C11H8ClNO2 |
| Molecular Weight | 221.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(2-chlorophenyl)-3-methylenedihydro-1H-pyrrole-2,5-dione.
1-(2-chlorophenyl)-3-methylenedihydro-1H-pyrrole-2,5-dione (CAS 37010-60-9) is a high-purity analytical reference standard with the molecular formula C11H8ClNO2 and a molecular weight of 221.64 g/mol.
1-(2-chlorophenyl)-3-methylenedihydro-1H-pyrrole-2,5-dione (C11H8ClNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(2-chlorophenyl)-3-methylenedihydro-1H-pyrrole-2,5-dione meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H8ClNO2 |
| Molecular Weight | 221.64 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related chlorophenyl Standards
- 5-(3-Chlorophenyl)-1h-pyrrole-2-carboxylic acid (CAS 1048917-65-2)
- 5-(2-Chlorophenyl)-1h-pyrrole-2-carboxylic acid (CAS 1048919-09-0)
- 3-(4-Chlorophenyl)-1H-pyrazole-4-carbaldehydeoxime (CAS 1199253-23-0)
- 5-(4-Chlorophenyl)-3-methylisoxazole-4-carbaldehyde (CAS 1208081-07-5)
- 5-(3-Chlorophenyl)-3-methylisoxazole-4-carbaldehyde (CAS 1208081-72-4)
- 4-(4-Chlorophenyl)-1H-pyrrole-3-carboxylic acid (CAS 122453-98-9)
- 3-(4-Chlorophenyl)-6-methyl-1,2,4-triazin-5(2H)-one (CAS 126542-93-6)
- 3-(4-Chlorophenyl)-5-methylisoxazole-4-carbaldehyde (CAS 127426-59-9)
Recommended Standards
- 1-(2-Chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one (CAS 60850-73-9)
- 1-(3-(3-Chlorophenyl)isoxazol-5-yl)ethanone (CAS 889939-01-9)
- 1-(2-Chlorophenyl)-1H-pyrrole-2-carboxylic acid (CAS 952958-66-6)
- 1-(3-(4-Chlorophenyl)isoxazol-5-yl)ethan-1-one (CAS 37091-33-1)
- Methyl 3-bromo-1H-indazole-6-carboxylate (CAS 192945-56-5)
- Tetrahydroberberine (CAS 522-97-4)
- (S)-tert-Butyl 3-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate (CAS 1217737-76-2)
- Terrestroside B (CAS 300817-18-9)
- 4-(Isopropylamino)-2H-chromen-2-one (CAS 887575-53-3)
- (-)-Citrinin-13C,d2 1329611-85-9 (CAS 1329611-85-9)
- 7-Methyl-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylic acid (CAS 95199-43-2)
- 1-([1,1'-Biphenyl]-4-yl)-3-tosylpropan-1-one (CAS 63472-09-3)
- Fluticasone Impurity 42 (CAS CATO-C4X-165042)
- Semaglutide impurity 214 (CAS CATO-C4X-2226214)
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