Cefoxitin EP Impurity H CAS 37051-05-1
| CAS No. | 37051-05-1 |
| Molecular Formula | C15H15N3O6S2 |
| Molecular Weight | 397.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Cefoxitin EP Impurity H.
As a process- or degradation-related impurity, Cefoxitin EP Impurity H (CAS 37051-05-1, C15H15N3O6S2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Cefoxitin EP Impurity H (C15H15N3O6S2) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 397.43 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Cefoxitin EP Impurity H meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H15N3O6S2 |
| Molecular Weight | 397.43 g/mol |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 2 |
Related Cefoxitin Standards
- Cefoxitin Impurity 54 (CAS CATO-C4X-157854)
- Cefoxitin Impurity 37 (CAS CATO-C4X-157837)
- Cefoxitin EP Impurity A (CAS 1158963-31-5)
- Cefoxitin EP Impurity A (CAS 54333-94-7)
- Cefoxitin Impurity 35 (R-Isomer) (CAS CATO-C4X-157835)
- Cefoxitin Impurity 36 (S-Isomer) (CAS CATO-C4X-157836)
- Cefoxitin Impurity 27 (CAS CATO-C4X-157827)
- Cefoxitin Impurity 28 (CAS CATO-C4X-157828)
Recommended Standards
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- Isoniazid Impurity 11 (CAS 4813-02-9)
- Raltitrexed Impurity 47 (CAS 1309031-82-0)
- Fluocinolone Acetonide Impurity 38 (CAS CATO-C4X-238138)
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