(E)-3-(3-Bromo-4-fluorophenyl)acrylic acid CAS 370867-85-9
| CAS No. | 370867-85-9 |
| Molecular Formula | C9H6BrFO2 |
| Molecular Weight | 245.05 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (E)-3-(3-Bromo-4-fluorophenyl)acrylic acid.
(E)-3-(3-Bromo-4-fluorophenyl)acrylic acid (CAS 370867-85-9) is a high-purity analytical reference standard with the molecular formula C9H6BrFO2 and a molecular weight of 245.05 g/mol.
The molecular framework of (E)-3-(3-Bromo-4-fluorophenyl)acrylic acid (C9H6BrFO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), (E)-3-(3-Bromo-4-fluorophenyl)acrylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H6BrFO2 |
| Molecular Weight | 245.05 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Br-containing |
Related E Standards
- 8-Bromo-5-fluorochroman-4-one (CAS 1092348-60-1)
- 6-Bromo-8-fluorochroman-4-one (CAS 1092348-68-9)
- 6-Bromo-7-fluorochroman-4-one (CAS 1092350-30-5)
- 7-Bromo-5-fluorochroman-4-one (CAS 1092350-58-7)
- 7-Bromo-8-fluorochroman-4-one (CAS 1092350-77-0)
- 8-Bromo-6-fluorochroman-4-one (CAS 1092350-87-2)
- 3-Bromo-2-fluorocinnamic acid (CAS 1214791-57-7)
- 5-Bromo-7-fluoro-2-methylbenzofuran-3(2H)-one (CAS 1248174-02-8)
Recommended Standards
- (E)-3-(2-Bromo-5-fluorophenyl)acrylic acid (CAS 939410-87-4)
- (E)-3-(4-Bromo-2-fluorophenyl)acrylic acid (CAS 575469-65-7)
- (8-Bromo-3-fluoroimidazo[1,2-a]pyridin-2-yl)methanol (CAS 2306275-00-1)
- 2-Bromo-4-fluorocinnamic acid (CAS 289038-17-1)
- 5-Azaspiro[3.5]nonane (CAS 160499-09-2)
- (S)-3-methylpent-1-yne (CAS 2868-07-7)
- 2-Fluoro-6-hydroxy-4-(trifluoromethyl)benzaldehyde (CAS 1823327-58-7)
- 4-(Propan-2-yloxy)-2-(trifluoromethyl)aniline hydrochloride (CAS 1258639-73-4)
- 3-[(3-aminophenyl)formamido]propanamide hydrochloride (CAS 1258641-50-7)
- (S)-6-Fluorospiro[chromane-2,1'-cyclobutan]-4-ol (CAS 1604261-88-2)
- 2-(3,4-Diethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1005009-95-9)
- 2-Propenamide, polymer with N,N-di-2-propen-1-ylcyclohexanamine and N-2-propen-1-ylcyclohexanamine, hydrochloride (CAS 102616-54-6)
- (+)-N-Desmethyl Tramadol (CAS 147762-57-0)
- Q-Peptide trifluoroacetate salt (CAS 1361235-89-3)
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