3-Hydroxy-1-(5-methyl-1,3,4-thiadiazol-2-yl)-4-(4-methylbenzoyl)-5-(p-tolyl)-1H-pyrrol-2(5H)-one CAS 371139-87-6
| CAS No. | 371139-87-6 |
| Molecular Formula | C22H19N3O3S |
| Molecular Weight | 405.47 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-Hydroxy-1-(5-methyl-1,3,4-thiadiazol-2-yl)-4-(4-methylbenzoyl)-5-(p-tolyl)-1H-pyrrol-2(5H)-one (CAS 371139-87-6) is a high-purity analytical reference standard with the molecular formula C22H19N3O3S and a molecular weight of 405.47 g/mol.
Structurally, 3-Hydroxy-1-(5-methyl-1,3,4-thiadiazol-2-yl)-4-(4-methylbenzoyl)-5-(p-tolyl)-1H-pyrrol-2(5H)-one (C22H19N3O3S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 405.47 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H19N3O3S |
| Molecular Weight | 405.47 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
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Recommended Standards
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- (E)-1-(2-chlorophenyl)-3-(dimethylamino)prop-2-en-1-one (CAS 75175-78-9)
- 4-(benzyloxy)-3,5-dimethylbenzene-1-sulfonyl chloride (CAS 1016516-29-2)
- 4-Cyclopropoxy-5-formyl-N-methylnicotinamide (CAS 1243464-29-0)
- (3R,4R)-4-aminooxan-3-ol hydrochloride (CAS 1523530-38-2)
- Fmoc-N-Aminopropyl-Gly(Alloc)-OH (CAS 174800-19-2)
- 2-(1,3,4-Oxadiazol-2-yl)ethan-1-amine (CAS 944907-22-6)
- 2-(Thiophen-2-ylmethylene)malononitrile (CAS 28162-32-5)
- Tert-butyl (2,5-dioxotetrahydrofuran-3-yl)carbamate (CAS 120409-48-5)
- Pancreatic Polypeptide (31-36), amide, human (CAS 74012-13-8)
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