Rosuvastatin Impurity 255 CAS 371775-71-2
| CAS No. | 371775-71-2 |
| Molecular Formula | C15H18FN3O3S |
| Molecular Weight | 339.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Rosuvastatin Impurity 255 (CAS 371775-71-2, C15H18FN3O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C15H18FN3O3S, Rosuvastatin Impurity 255 contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 339.39 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Rosuvastatin Impurity 255 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H18FN3O3S |
| Molecular Weight | 339.39 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Rosuvastatin Standards
- Rosuvastatin Related Compound 46 (CAS 953776-62-0)
- Rosuvastatin Impurity 68 (CAS CATO-C4X-116968)
- Rosuvastatin Impurity 21 (CAS 147118-27-2)
- Rosuvastatin Impurity 165 (CAS CATO-C4X-1169165)
- Rosuvastatin Impurity 103 (CAS CATO-C4X-1169103)
- Rosuvastatin Impurity 259 (CAS CATO-C4X-1169259)
- Rosuvastatin Impurity 139 (CAS CATO-C4X-1169139)
- Rosuvastatin Impurity 192 (CAS 1092844-00-2)
Recommended Standards
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- N-((1-(methylthio)cyclopropyl)methyl)thietan-3-amine (CAS 1881374-18-0)
- N-(3,4-dimethylphenyl)thiolan-3-amine (CAS 1019589-26-4)
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