3,3,3-Trifluoro-2-hydroxy-2-methylpropanoic Acid CAS 374-35-6
| CAS No. | 374-35-6 |
| Molecular Formula | C4H5F3O3 |
| Molecular Weight | 158.08 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3,3,3-Trifluoro-2-hydroxy-2-methylpropanoic Acid is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3,3,3-Trifluoro-2-hydroxy-2-methylpropanoic Acid (CAS 374-35-6) is a high-purity analytical reference standard with the molecular formula C4H5F3O3 and a molecular weight of 158.08 g/mol.
3,3,3-Trifluoro-2-hydroxy-2-methylpropanoic Acid (C4H5F3O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3,3,3-Trifluoro-2-hydroxy-2-methylpropanoic Acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H5F3O3 |
| Molecular Weight | 158.08 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Trifluoro Standards
- (R)-4,4,4-Trifluoro-3-hydroxybutanoic Acid (CAS 108211-36-5)
- (S)-4,4,4-Trifluoro-3-hydroxybutanoic Acid (CAS 128899-79-6)
- (R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionic Acid (CAS 44864-47-3)
- 3,3,3-Trifluoro-2-hydroxypropanehydrazide (CAS 934175-01-6)
- 4,4,4-Trifluoro-2-hydroxybutanoic acid (CAS 879090-39-8)
- 4,4,4-Trifluoro-3-hydroxybutanoic Acid (CAS 86884-21-1)
- 4,4,4-Trifluoro-3-methoxybutan-1-ol (CAS 1086277-23-7)
- 1,2,5-Trifluoro-3-vinylbenzene (CAS 1210261-82-7)
Recommended Standards
- 2,5,6-Trifluoronicotinonitrile (CAS 870065-73-9)
- 2-(Trifluoromethyl)-3-hydroxypropionic Acid (CAS 382-43-4)
- 2-(2,2,2-Trifluoroethoxy)acetic acid (CAS 675-67-2)
- (E)-(3-(Trimethylsilyl)allyl)boronic acid (CAS 774597-15-8)
- [(15aS)-7,8,9,10-Tetrahydro-6H-dibenzo[b,d][1,6]dioxacycloundecin-1,15-diyl]bis[diphenylphosphine] (CAS 486429-95-2)
- 2-(Hydroxymethyl)-5-[(4-methoxybenzyl)oxy]pyridin-4(1H)-one (CAS 118679-90-6)
- 959238-42-7 2-(4-Methylmorpholin-2-yl)ethan-1-ol DTXSID80612160 (CAS 959238-42-7)
- 2-(Diphenylphosphino)-N-(1H-pyrrol-2-ylmethylene)benzenamine (CAS 649749-98-4)
- 2-(2,2-Dicyclohexylethyl)piperidine (CAS 39648-48-1)
- 1,2,5-Thiadiazole-3,4-diamine (CAS 55904-36-4)
- Sulfasalazine Impurity 2 (RRT 0.75) (CAS 139-56-0)
- Isopropyl 5-bromo-3-(((tert-butoxycarbonyl)amino)methyl)picolinate (CAS 863444-54-6)
- Ethyl 2-(5-chloro-1-methyl-1h-imidazol-2-yl)acetate hydrochloride (CAS 1211112-58-1)
- Peptide 439 (CAS CATO-CPTD788439)
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