5-(4-Fluorophenyl)-3-hydroxy-4-(4-methylbenzoyl)-1-(thiazol-2-yl)-1H-pyrrol-2(5H)-one CAS 374697-83-3
| CAS No. | 374697-83-3 |
| Molecular Formula | C21H15FN2O3S |
| Molecular Weight | 394.42 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-(4-Fluorophenyl)-3-hydroxy-4-(4-methylbenzoyl)-1-(thiazol-2-yl)-1H-pyrrol-2(5H)-one (CAS 374697-83-3), molecular formula C21H15FN2O3S and molecular weight 394.42 g/mol, is a CATO reference standard with documented purity and traceability.
5-(4-Fluorophenyl)-3-hydroxy-4-(4-methylbenzoyl)-1-(thiazol-2-yl)-1H-pyrrol-2(5H)-one (C21H15FN2O3S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 5-(4-Fluorophenyl)-3-hydroxy-4-(4-methylbenzoyl)-1-(thiazol-2-yl)-1H-pyrrol-2(5H)-one under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C21H15FN2O3S |
| Molecular Weight | 394.42 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Fluorophenyl Standards
- 2-{[(3-fluorophenyl)methyl]sulfanyl}-4-(trifluoromethyl)-5H,6H,7H,8H,9H,10H-cycloocta[b]pyridine-3-carbonitrile (CAS 626228-65-7)
- 9-(4-Fluorophenyl)-7-(thiophen-2-yl)thieno[2,3-b:4,5-b']dipyridine-2,4-diol (CAS 290300-02-6)
- 1-(4-Fluorophenyl)-5-methyl-N-(2-(4-methylpiperazin-1-yl)phenyl)-1H-1,2,4-triazole-3-carboxamide (CAS 338398-14-4)
- (2-(4-(Bis(4-fluorophenyl)methyl)piperazin-1-yl)phenyl)methanol (CAS 914349-61-4)
- (4-(4-(Bis(4-fluorophenyl)methyl)piperazin-1-yl)phenyl)methanol (CAS 914349-62-5)
- Ethyl 2-((3-(4-fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)butanoate (CAS 687562-47-6)
- 2-{[(4-fluorophenyl)methyl]sulfanyl}-5-{4H,5H-naphtho[1,2-b]thiophen-2-yl}-1,3,4-oxadiazole (CAS 478033-58-8)
- (4-Fluorophenyl)(5-(4-iodophenyl)-1H-1,2,4-triazol-3-yl)methanamine (CAS 1707585-73-6)
Recommended Standards
- 4,4'-((2,5-Dimethyl-1,4-phenylene)bis(ethyne-2,1-diyl))dibenzoicacid (CAS 2098914-21-5)
- 9-(2,6-Dimethoxyphenyl)-1,8-dimethoxy-9H-xanthen-9-ol (CAS 95431-58-6)
- 2-{[(2s)-1-{[(9h-fluoren-9-yl)methoxy]carbonyl}pyrrolidin-2-yl]formamido}acetic acid (CAS 250695-65-9)
- Barbigerone (CAS 75425-27-3)
- (2-Hydroxy-3-iodophenyl)boronic acid (CAS 1245635-13-5)
- L-Prolinanilide Hydrochloride (CAS 151240-17-4)
- [(2,5-difluorophenyl)thio]acetic acid (CAS 848178-43-8)
- 5-Ethynylthiophene-3-carboxylic acid (CAS 1849280-96-1)
- 3-(2,5-Difluorophenyl)propanenitrile (CAS 1057676-35-3)
- 1-(2-Nitrobenzyl)-1H-imidazole (CAS 61292-49-7)
- 2-((5-Chloro-7-iodoquinolin-8-yl)oxy)acetic acid (CAS 730949-78-7)
- 3-Pyridylacetic-α,α-d2 Acid-OD DCl (CAS 1219802-37-5)
- (E)-3-phenyl-1-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)prop-2-en-1-one (CAS 364333-61-9)
- Neuropeptide Y (22-36) (CAS 119019-65-7)
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