(S)-4,4-difluoro-N-(3-oxo-1-phenylpropyl)cyclohexane-1-carboxamide CAS 376348-78-6
| CAS No. | 376348-78-6 |
| Molecular Formula | C16H19F2NO2 |
| Molecular Weight | 295.32 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (S)-4,4-difluoro-N-(3-oxo-1-phenylpropyl)cyclohexane-1-carboxamide is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
(S)-4,4-difluoro-N-(3-oxo-1-phenylpropyl)cyclohexane-1-carboxamide (CAS 376348-78-6) is a high-purity analytical reference standard with the molecular formula C16H19F2NO2 and a molecular weight of 295.32 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, (S)-4,4-difluoro-N-(3-oxo-1-phenylpropyl)cyclohexane-1-carboxamide is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 295.32 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures (S)-4,4-difluoro-N-(3-oxo-1-phenylpropyl)cyclohexane-1-carboxamide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H19F2NO2 |
| Molecular Weight | 295.32 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
- (2Z)-2-(3-amino-1H-isoindol-1-ylidene)-2-cyano-N-1,3-thiazol-2-ylacetamide (CAS 790272-35-4)
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- Ethyl 5-((tert-butoxycarbonyl)amino)-4,4-difluoro-2-methylpentanoate (CAS 1404196-49-1)
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- 4-Bromo-2-(tert-butyl)-3-cyclopropoxypyridine (CAS 1243475-17-3)
- 3-(2,3-Dichlorophenyl)-5-methyl-1,2-oxazole-4-carboxylic acid (CAS 4402-75-9)
- 4-(Bromomethyl)pyridine hydrochloride (CAS 843673-58-5)
- Ethyl 1-cyclopropyl-1H-1,2,3-triazole-4-carboxylate (CAS 1353636-78-8)
- 5-(3-Phenoxy-phenyl)-[1,3,4]thiadiazol-2-ylamine (CAS 383130-76-5)
- Tofacitinib Impurity 103 (CAS CATO-C4X-1079103)
- 3-(2-Fluoro-6-(pyrrolidin-1-yl)pyridin-3-yl)prop-2-yn-1-ol (CAS 1228666-51-0)
- 2-(Bicyclo[3.1.1]heptan-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2609867-69-6)
- 3,3-Dimethylbutanethioamide (CAS 58065-61-5)
- Cyclolinopeptide B (CAS 193139-41-2)
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