Tenofovir Alafenamide Impurity 22 CAS 376633-26-0
| CAS No. | 376633-26-0 |
| Molecular Formula | C15H25N6O5P |
| Molecular Weight | 400.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Tenofovir Alafenamide Impurity 22 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Tenofovir Alafenamide Impurity 22 (CAS 376633-26-0, C15H25N6O5P) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Tenofovir Alafenamide Impurity 22 (C15H25N6O5P) contains a nitrogen-containing heterocyclic scaffold, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 6.5, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 400.37 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C15H25N6O5P |
| Molecular Weight | 400.37 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 6 |
Related Tenofovir Standards
- Tenofovir disoproxil Impurity 135 (CAS CATO-C4X-1076135)
- Tenofovir Alafenamide Impurity 30 (CAS CATO-C4X-179730)
- Tenofovir Impurity 62 (CAS 211364-69-1)
- Tenofovir disoproxil Impurity 140 (CAS CATO-C4X-1076140)
- Tenofovir alafenamide Impurity 93 (CAS CATO-C4X-179793)
- Tenofovir alafenamide Impurity 13 (CAS 851456-00-3(Free Base))
- Tenofovir Alafenamide 64 (CAS CATO-C4X-179764)
- Tenofovir alafenamide Impurity 96 (CAS CATO-C4X-179796)
Recommended Standards
- Desphenyl Tenofovir Alafenamide (CAS CATO-C4X-179759)
- Methyl 4-[3-(thiophen-2-yl)-3-(2,2,2-trifluoroacetamido)propanamido]benzoate (CAS 861209-43-0)
- Regaloside A (CAS 114420-66-5)
- Methyl 2-(((4-((2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)methyl)phenyl)carbamoyl)thio)acetate (CAS 339025-65-9)
- Dalilesen impurity 48 (CAS CATO-C4X-301048)
- Procaterol Impurity 24 (CAS CATO-C4X-181024)
- Tirofiban Impurity 77 (CAS 13022-41-8)
- Prilocaine Impurity 22 (CAS 2384559-40-2)
- 5-Nitro-2-(pyrrolidin-1-yl)benzaldehyde (CAS 30742-59-7)
- Dibenzyl Phthalate (CAS 523-31-9)
- 1-Chloro-2,4-difluoro-5-methylbenzene (CAS 885267-23-2)
- exo-6-(Methoxymethyl)-3-azabicyclo[3.1.0]hexane (CAS 504437-80-3)
- 2-Propenoic acid, 2-methyl-, sodium salt , polymer with diethenylbenzene (CAS 63182-04-7)
- Palmitoyl Hexapeptide-12 (CAS 171263-26-6)
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