7-Nitro-5-(trifluoromethyl)benzo[d]thiazol-2(3H)-one CAS 37681-12-2
| CAS No. | 37681-12-2 |
| Molecular Formula | C8H3F3N2O3S |
| Molecular Weight | 264.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 7-Nitro-5-(trifluoromethyl)benzo[d]thiazol-2(3H)-one.
CATO supplies 7-Nitro-5-(trifluoromethyl)benzo[d]thiazol-2(3H)-one (CAS 37681-12-2), a certified reference material (molecular formula C8H3F3N2O3S, MW 264.18 g/mol) for analytical method development and quality control.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution, 7-Nitro-5-(trifluoromethyl)benzo[d]thiazol-2(3H)-one is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 264.18 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 7-Nitro-5-(trifluoromethyl)benzo[d]thiazol-2(3H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H3F3N2O3S |
| Molecular Weight | 264.18 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Nitro Standards
- 3-Methyl-4-nitro-1-(4-nitrophenyl)-1h-pyrazol-5-ol (CAS 132-42-3)
- 2-Nitro-5-(pentafluoro-λ6-sulfanyl)aniline (CAS 1379803-65-2)
- 2-(4-Nitro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoic acid (CAS 18627-60-6)
- Ethyl 4-nitro-1,3-dioxoisoindoline-2-carboxylate (CAS 190910-88-4)
- (3-Nitro-2-oxo-2H-chromen-4-yl)glycine (CAS 78795-04-7)
- (S)-2-(4-Nitro-1,3-dioxoisoindolin-2-yl)propanoic acid (CAS 76582-11-1)
- 2-(Methyl(2-nitro-4-(trifluoromethyl)phenyl)amino)ethanol (CAS 103748-04-5)
- 3-((4-Nitro-2-(trifluoromethyl)phenyl)amino)propan-1-ol (CAS 115416-49-4)
Recommended Standards
- 2-((3bR,4aS)-3-(Difluoromethyl)-5,5-difluoro-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetic acid (CAS 1626337-86-7)
- Gemcitabine Impurity 14 (CAS 294177-31-4)
- 2-((3bS,4aR)-3-(Difluoromethyl)-5,5-difluoro-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetic acid (CAS 1626337-85-6)
- Gemcitabine Impurity 20 (CAS 153381-14-7)
- N-Benzyl-5-bromo-3-methyl-2-pyridinamine (CAS 1219976-47-2)
- 3-Hydroxy-5-phenylbenzamide (CAS 1400644-43-0)
- 2-bromo-4,5-dimethoxy-N-methylbenzenesulfonamide (CAS 923126-56-1)
- 4-[2-(4-Chloro-2-nitrophenoxy)ethyl]piperidinehydrochloride (CAS 1220031-22-0)
- 2-(4-Ethylcyclohexyl)-2-hydroxyacetic acid (CAS 1483591-17-8)
- 1-(2-Chloro-6-methylphenyl)piperazine (CAS 80835-95-6)
- Gadobenate Dimeglumine Impurity 2 (CAS 71231-87-3)
- 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic Acid (CAS 1001413-01-9)
- 4-Ethylamino-2-methanethiopyrimidine-5-carboxaldehyde (CAS 185040-35-1)
- Characteristic MSH-Tetrapeptide (CAS 4289-02-5)
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