3,3,4,4-tetrafluoropyrrolidine-2,5-dione CAS 377-33-3

Purity 97%+In StockPharmaceutical Standards
CAS No.377-33-3
Molecular FormulaC4HF4NO2
Molecular Weight171.05 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

3,3,4,4-tetrafluoropyrrolidine-2,5-dione CAS 377-33-3 chemical structure

Description

The occurrence of 3,3,4,4-tetrafluoropyrrolidine-2,5-dione is closely related to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

3,3,4,4-tetrafluoropyrrolidine-2,5-dione (CAS 377-33-3), molecular formula C4HF4NO2 and molecular weight 171.05 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 3,3,4,4-tetrafluoropyrrolidine-2,5-dione (C4HF4NO2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

CATO manufactures 3,3,4,4-tetrafluoropyrrolidine-2,5-dione under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.

Physical & Chemical Properties

Molecular FormulaC4HF4NO2
Molecular Weight171.05 g/mol
AppearanceWhite to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)3.0
UV AbsorptionUV-absorbing
CAS Registry Year (est.)1957
Halogen ContentF-containing
Nitrogen Atoms1

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