N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4-amine CAS 379230-38-3
| CAS No. | 379230-38-3 |
| Molecular Formula | C20H17ClFN3O4 |
| Molecular Weight | 417.82 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 417.82 g/mol gives N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4-amine distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4-amine (CAS 379230-38-3), a certified reference material (molecular formula C20H17ClFN3O4, MW 417.82 g/mol) for analytical method development and quality control.
The molecular framework of N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4-amine (C20H17ClFN3O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H17ClFN3O4 |
| Molecular Weight | 417.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related N Standards
- Ethyl 2-(3-chlorobenzo[b]thiophene-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (CAS 313960-53-1)
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- N-(5-(5-chlorobenzo[d]oxazol-2-yl)-2-methylphenyl)-3-methyl-4-nitrobenzamide (CAS 400740-94-5)
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- N-(3-(6-Chlorobenzo[d]oxazol-2-yl)-5-methylphenyl)-4-ethoxybenzamide (CAS 590396-53-5)
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Recommended Standards
- BTB06584 (CAS 219793-45-0)
- (E)-[(5-{[(2-chlorophenyl)methyl]sulfanyl}-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methylidene]amino cyclopropanecarboxylate (CAS 321553-58-6)
- Pantoprazole Impurity 51 (CAS 812664-93-0)
- 2,4,6-Tribromo-5-amino-isophthalic acid (CAS 35453-30-6)
- 2-Amino-2-methylpropane-1-thiol hydrochloride (CAS 4146-00-3)
- 3-(4-Chloro-3-methyl-1h-pyrazol-1-yl)propan-1-amine (CAS 951235-35-1)
- Phenothiazine Impurity 6 (CAS 28140-93-4)
- 2-Methyl-6-(methylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 1420297-13-7)
- 3,4-Dihydro-1H-2-benzopyran-5-carboxylic acid (CAS 1261601-88-0)
- Tert-butyl 4-((4-ethynylphenyl)sulfonyl)piperazine-1-carboxylate (CAS 1162257-02-4)
- Benzopyrene Related Compound 9 (CAS 57303-98-7)
- 1-Bromo-4-propylcyclohex-1-ene (CAS 1033202-23-1)
- Quetiapine EP Impurity S DiHCl (CAS 329218-11-3)
- Semaglutide impurity 23 (CAS CATO-C4X-222623)
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