2-Tert-butyl-4-[(4-chlorophenyl)methylidene]-1,2,3,4-tetrahydroacridine-9-carboxylic acid CAS 380437-35-4
| CAS No. | 380437-35-4 |
| Molecular Formula | C25H24ClNO2 |
| Molecular Weight | 405.92 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-Tert-butyl-4-[(4-chlorophenyl)methylidene]-1,2,3,4-tetrahydroacridine-9-carboxylic acid is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-Tert-butyl-4-[(4-chlorophenyl)methylidene]-1,2,3,4-tetrahydroacridine-9-carboxylic acid (CAS 380437-35-4), molecular formula C25H24ClNO2 and molecular weight 405.92 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Tert-butyl-4-[(4-chlorophenyl)methylidene]-1,2,3,4-tetrahydroacridine-9-carboxylic acid (C25H24ClNO2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H24ClNO2 |
| Molecular Weight | 405.92 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- 2-Tert-butyl-4-[(3-chlorophenyl)methylidene]-1,2,3,4-tetrahydroacridine-9-carboxylic acid (CAS 380436-75-9)
- 3-((4-Chlorobenzyl)sulfonyl)-N-(p-tolyl)thiophene-2-carboxamide (CAS 251097-11-7)
- 2-(4-Chlorobenzenesulfinyl)-3-methanesulfonyl-4-methyl-6-phenylpyridine (CAS 339017-09-3)
- 3,5-Bis(bromomethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (CAS 2096469-95-1)
- 5-(1,5-Dimethyl-1H-benzo[d]imidazol-2-yl)-1,3,4-oxadiazol-2(3H)-one (CAS 87802-15-1)
- Tert-butyl (3-(trifluoromethyl)cyclohexyl)carbamate (CAS 1494503-84-2)
- Ethyl 1-(ethylsulfonyl)piperidine-3-carboxylate (CAS 869951-27-9)
- Methyl 4-Amino-5-(ethylsulfonyl)-2-methoxybenzoate (CAS 80036-89-1)
- Oxiran-2-ylmethyl 4-(tert-butyl)benzoate (CAS 59313-58-5)
- Ethyl 4-chloro-7-methylpyrazolo[1,5-a][1,3,5]triazine-2-carboxylate (CAS 2365243-36-1)
- 6-Methyl-5-nitropiperidin-2-one (CAS 1006713-07-0)
- 3-Amino-N-(2,4-dimethylphenyl)-4-methylbenzene-1-sulfonamide (CAS 326023-20-5)
- (R)-N-(pyrrolidin-2-ylmethyl)acetamide hydrochloride (CAS 1449137-51-2)
- Gastrin Tetrapeptide (CAS 1947-37-1)
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