Ethyl 3-amino-2,2-difluoro-3-phenylpropanoate CAS 381245-54-1
| CAS No. | 381245-54-1 |
| Molecular Formula | C11H13F2NO2 |
| Molecular Weight | 229.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 229.22 g/mol gives Ethyl 3-amino-2,2-difluoro-3-phenylpropanoate distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Ethyl 3-amino-2,2-difluoro-3-phenylpropanoate (CAS 381245-54-1), molecular formula C11H13F2NO2 and molecular weight 229.22 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Ethyl 3-amino-2,2-difluoro-3-phenylpropanoate (C11H13F2NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), Ethyl 3-amino-2,2-difluoro-3-phenylpropanoate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H13F2NO2 |
| Molecular Weight | 229.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ethyl Standards
- Ethyl 3-amino-3-(2,5-difluorophenyl)propanoate (CAS 1096828-54-4)
- Methyl 4-amino-4-(2,4-difluorophenyl)butanoate (CAS 1178716-80-7)
- Methyl 4-amino-4-(3,4-difluorophenyl)butanoate (CAS 1183428-86-5)
- methyl 2-amino-5-(trifluoromethyl)thiophene-3-carboxylate (CAS 1574635-45-2)
- Ethyl 3-amino-3-(2,4-difluorophenyl)propanoate (CAS 502842-41-3)
- 2-Amino-3-phenoxybenzoic acid (CAS 1039878-63-1)
- 4-Amino-5-fluoro-1-((2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (CAS 107036-62-4)
- Methyl3-amino-6-phenylpyridazine-4-carboxylate (CAS 1099794-24-7)
Recommended Standards
- Ethyl (R)-3-amino-3-(2,4-difluorophenyl)propanoate (CAS 612532-15-7)
- 8-(Trifluoromethyl)quinoline-4-thiol (CAS 550346-16-2)
- Methyl (R)-3-amino-4-(2,5-difluorophenyl)butanoate (CAS 848667-53-8)
- 6-(Trifluoromethyl)quinoline-4-thiol (CAS 544716-08-7)
- 5-Amino-1-benzofuran-2-carboxylic acid (CAS 42933-44-8)
- 2-(Phenylmethoxy)-4-pyrimidinamine (CAS 60722-67-0)
- Ethyl 4-(3-chloro-1H-1,2,4-triazol-1-yl)butanoate (CAS 1823402-73-8)
- 2-Bromo-3-fluoropyrazine (CAS 206278-27-5)
- 4-Chlorotetrahydro-2H-pyran (CAS 1768-64-5)
- n-(Sec-butyl)-5-(((difluoromethyl)thio)methyl)furan-2-carboxamide (CAS 1223186-51-3)
- 2-(Piperidin-1-yl)ethane-1-sulfonyl chloride (CAS 1062293-75-7)
- o-CYMEN-5-OL (CAS 39660-61-2)
- 3-Amino-4-fluoro-1-isopropylpyridin-2(1H)-one (CAS 2271474-62-3)
- Liraglutide Impurity 18 TFA Salt (CAS CATO-C4X-199218)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com