3-bromo-1-benzofuran-2-carbaldehyde CAS 38281-52-6
| CAS No. | 38281-52-6 |
| Molecular Formula | C9H5BrO2 |
| Molecular Weight | 225.04 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-bromo-1-benzofuran-2-carbaldehyde.
3-bromo-1-benzofuran-2-carbaldehyde (CAS 38281-52-6) is a high-purity analytical reference standard with the molecular formula C9H5BrO2 and a molecular weight of 225.04 g/mol.
The molecular framework of 3-bromo-1-benzofuran-2-carbaldehyde (C9H5BrO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H5BrO2 |
| Molecular Weight | 225.04 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | Br-containing |
Related bromo Standards
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- 4-Bromo-1H-pyrrolo[3,2-c]pyridine-3-carbaldehyde (CAS 1000341-87-6)
- 5-Bromo-1,6-naphthyridin-2-ol (CAS 105276-96-8)
- 4-Bromo-2-(furan-3-yl)pyrimidine (CAS 1086381-95-4)
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Recommended Standards
- 3-Bromo-1,8-naphthyridin-4-ol (CAS 58708-43-3)
- 3-Bromo-2H-chromen-2-one (CAS 939-18-4)
- 3-Bromo-1,8-naphthyridin-2-ol (CAS 56247-28-0)
- 3-Bromo-4H-pyrido[1,2-a]pyrimidin-4-one (CAS 500699-73-0)
- N1-Isopropyl-N1-(4-(methylthio)benzyl)ethane-1,2-diamine (CAS 1353959-16-6)
- 1,3-Diethyl 2-phenyl-2-(prop-2-en-1-yl)propanedioate (CAS 50790-26-6)
- Eglin c (60-63)-methyl ester (CAS 131696-94-1)
- 12-Hydroxydodecyl Methacrylate (CAS 86282-42-0)
- 6-Bromo-3-methylbenzofuran-2-carboxamide (CAS 35351-28-1)
- 3-(6-(5-(1-Cyclopentyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl)pentanenitrile (CAS 1956379-63-7)
- 3-((Ethylamino)methyl)pentan-3-ol (CAS 1312607-91-2)
- 4H-1,2,4-triazol-3-amine (CAS 65312-61-0)
- CAS 634908-42-2 (CAS 634908-42-2)
- Semaglutide Impurity 183 (CAS 159541-28-3)
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