4-{3-[4-(2-Fluorophenyl)piperazino]-2-hydroxypropoxy}benzenecarbonitrile CAS 383145-99-1
| CAS No. | 383145-99-1 |
| Molecular Formula | C20H22FN3O2 |
| Molecular Weight | 355.41 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-{3-[4-(2-Fluorophenyl)piperazino]-2-hydroxypropoxy}benzenecarbonitrile (C20H22FN3O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
4-{3-[4-(2-Fluorophenyl)piperazino]-2-hydroxypropoxy}benzenecarbonitrile (CAS 383145-99-1), molecular formula C20H22FN3O2 and molecular weight 355.41 g/mol, is a CATO reference standard with documented purity and traceability.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4-{3-[4-(2-Fluorophenyl)piperazino]-2-hydroxypropoxy}benzenecarbonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H22FN3O2 |
| Molecular Weight | 355.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Fluorophenyl Standards
- N-(4-(3-(4-Fluorophenyl)ureido)cyclohexyl)benzamide (CAS 1956318-69-6)
- 4-(3-(4-(4-Fluorophenyl)piperazin-1-yl)-2-hydroxypropoxy)benzonitrile (CAS 383147-03-3)
- 1-(5-(4-Fluorophenyl)-5-hydroxypentanoyl)-5-phenylpyrrolidin-2-one (CAS 1027552-46-0)
- N-(2-((4-(2-Fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)cyclopropanecarboxamide (CAS 897613-37-5)
- N-(2-((5-(4-Fluorophenyl)-1H-imidazol-2-yl)thio)ethyl)-2-phenylacetamide (CAS 897456-15-4)
- 2-((5-(2-Fluorophenyl)-1,3,4-oxadiazol-2-yl)thio)-1-(indolin-1-yl)ethanone (CAS 571904-77-3)
- Ethyl 5-((4-fluorophenyl)thio)-3-phenyl-1,2,4-triazine-6-carboxylate (CAS 338957-33-8)
- 2-(4-(2-Fluorophenyl)piperazin-1-yl)-N-(4-isopropylphenyl)acetamide (CAS 329080-41-3)
Recommended Standards
- 4-(3,4-Dihydroxyphenyl)-6-methyl-N-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide (CAS 5985-95-5)
- 4-Acetyl-N-(3-methyl-1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide (CAS 494189-46-7)
- 4-Ethoxy-N-(5-(2-(methylthio)phenyl)-1,3,4-oxadiazol-2-yl)benzamide (CAS 886910-32-3)
- 3-Hydroxy-1-{5-hydroxy-3-methyl-1-[4-(4-methylphenyl)-1,3-thiazol-2-yl]-1H-pyrazol-4-yl}-2-buten-1-one (CAS 245039-18-3)
- tert-butyl N-(azepan-4-ylmethyl)carbamate (CAS 1408074-78-1)
- [(1R)-[1,1'-Binaphthalene]-2,2'-diylbis[diphenylphosphine-κP]](η3-2-propenyl)-Palladium chloride (CAS 879689-47-1)
- 5-Bromo-2-ethylisoindoline-1,3-dione (CAS 351992-19-3)
- 1-(Benzo[d][1,3]dioxol-5-yl)-3-((2,4-dimethoxyphenyl)amino)propan-1-one (CAS 477319-03-2)
- Formoterol Impurity N1 (CAS 43229-66-9)
- 1-[3,7-Bis(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-6-yl]-3,5-dimethyl-1H-pyrazole (CAS 957003-27-9)
- N-Formyl Ephedrine (Mixture of Diastereomers) (CAS 91246-94-5)
- 2-Bromo-5-isocyanatopyridine (CAS 1260671-10-0)
- 1-Acetyl-N-ethylpiperidine-3-carboxamide (CAS 1158509-97-7)
- Calcitonin C-Terminal Flanking Peptide (human) XTFA (CAS 85916-47-8（free base）)
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