1-Boc-4-(4-Chloroquinazolin-6-ylethynyl)piperidine CAS 383434-51-3
| CAS No. | 383434-51-3 |
| Molecular Formula | C20H22ClN3O2 |
| Molecular Weight | 371.86 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 371.86 g/mol gives 1-Boc-4-(4-Chloroquinazolin-6-ylethynyl)piperidine distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
1-Boc-4-(4-Chloroquinazolin-6-ylethynyl)piperidine (CAS 383434-51-3), molecular formula C20H22ClN3O2 and molecular weight 371.86 g/mol, is a CATO reference standard with documented purity and traceability.
1-Boc-4-(4-Chloroquinazolin-6-ylethynyl)piperidine (C20H22ClN3O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-Boc-4-(4-Chloroquinazolin-6-ylethynyl)piperidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H22ClN3O2 |
| Molecular Weight | 371.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Boc Standards
- Propyl 4-((6-chloroquinazolin-4-yl)thio)piperidine-1-carboxylate (CAS 325146-08-5)
- N-((5-(4-chloroquinazolin-6-yl)furan-2-yl)methyl)-2-(methylsulfonyl)ethan-1-amine (CAS 1334953-75-1)
- Ethyl 4-((6-chloroquinazolin-4-yl)thio)piperidine-1-carboxylate (CAS 325146-05-2)
- 2-((7-Chloroquinazolin-4-yl)amino)-1-(naphthalen-2-yl)ethan-1-ol (CAS 477870-05-6)
- 2-(2-Chloroquinazolin-4-yl)-9-phenyl-9H-carbazole (CAS 1616499-37-6)
- Methyl 4-((6-chloroquinazolin-4-yl)thio)piperidine-1-carboxylate (CAS 325146-07-4)
- 1797996-68-9 4-Chloroquinazolin-2-yl)(quinolin-2-yl)methanone (CAS 1797996-68-9)
- 2-((7-Chloroquinazolin-4-yl)amino)benzoic acid (CAS 90430-16-3)
Recommended Standards
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- 1-[6-(4-Chlorophenoxy)hexyl]-3-cyano-2-pyridin-4-ylguanidine (CAS 200484-11-3)
- 3-Chloro-N-(4-(pyridin-2-yl)thiazol-2-yl)benzo[b]thiophene-2-carboxamide (CAS 361479-25-6)
- 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)quinoxalin-2(1H)-one (CAS 1209498-40-7)
- Pyrrolidin-2-one oxime hydrochloride (CAS 14299-99-1)
- 3-Iodo-5,7-dimethylquinolin-4(1H)-one (CAS 1330750-83-8)
- N1-Benzyl-N1-(pyridin-2-yl)ethane-1,2-diamine (CAS 50331-70-9)
- 3-(((Trifluoromethyl)sulfinyl)methyl)azetidine (CAS 1499451-23-8)
- 1-Bromo-2-(fluoromethyl)-4-(trifluoromethyl)benzene (CAS 2244088-55-7)
- Ethyl 5-isobutyl-1,2,4-oxadiazole-3-carboxylate (CAS 1385696-43-4)
- 4-(2-Hydrazinylthiazol-4-yl)-2-methoxyphenol (CAS 886493-54-5)
- 6-(2,2-difluoroethoxy)pyridine-2-carboxamide (CAS 1803605-31-3)
- Tirzepatide-d7 Ditrifluoroacetate (CAS CATO-CPTD788698)
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