6-Fluorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide CAS 384-45-2

Description

The occurrence of 6-Fluorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide is closely related to an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

6-Fluorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (CAS 384-45-2), molecular formula C7H4FNO3S and molecular weight 201.17 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 6-Fluorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (C7H4FNO3S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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