2-Amino-4-methoxybenzonitrile CAS 38487-85-3
| CAS No. | 38487-85-3 |
| Molecular Formula | C8H8N2O |
| Molecular Weight | 148.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Amino-4-methoxybenzonitrile.
2-Amino-4-methoxybenzonitrile (CAS 38487-85-3), molecular formula C8H8N2O and molecular weight 148.16 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Amino-4-methoxybenzonitrile (C8H8N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Amino-4-methoxybenzonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H8N2O |
| Molecular Weight | 148.16 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Nitrogen Atoms | 2 |
Related Amino Standards
- 2-Amino-4-hydroxy-3-methylbenzonitrile (CAS 102569-26-6)
- 2-Amino-3-(2-aminoethoxy)propanoic acid (CAS 10367-17-6)
- 3-Amino-4-methylbenzisoxazole (CAS 1126636-46-1)
- 2-Amino-3-(hydroxymethyl)benzonitrile (CAS 114344-01-3)
- 2-Amino-7-methylbenzoxazole (CAS 1268154-07-9)
- 5-Amino-1H-indol-2-ol (CAS 1395493-23-8)
- 2-amino-3-methoxybenzonitrile (CAS 148932-68-7)
- 2-Amino-6-methoxybenzonitrile (CAS 1591-37-3)
Recommended Standards
- 2-amino-3-hydroxy-4-methylbenzonitrile (CAS 344615-05-0)
- 2-Amino-4-methylbenzoxazole (CAS 947504-99-6)
- 2-Amino-3H-indol-4-ol (CAS 204275-64-9)
- 2-Amino-5-methoxybenzonitrile (CAS 23842-82-2)
- 2-(((3-Methoxypyrazin-2-yl)methyl)amino)acetic acid (CAS 1353979-03-9)
- tert-butyl 3-amino-3-methylpyrrolidine-1-carboxylate (CAS 1158758-59-8)
- 6-Chloro-4-nitro-3-(trifluoromethyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine (CAS 892414-51-6)
- 3-Cyclopropoxy-5-isopropylbenzenesulfonamide (CAS 1243376-35-3)
- 2-Methyl-1,2,3,4-tetrahydroisoquinolin-7-ol (CAS 88493-58-7)
- (R)-2-fluoro-4-hydroxy-5-(pyrrolidin-2-yl)benzonitrile (CAS 1212853-66-1)
- 5-Methylisobenzofuran-1(3H)-one (CAS 54120-64-8)
- 7-Chloro-2-(3,4-dichlorophenyl)-4H-benzo[d][1,3]oxazin-4-one (CAS 332033-38-2)
- Methyl 2-((9-methyl-5H-thiochromeno[4,3-d]pyrimidin-2-yl)thio)acetate (CAS 478246-78-5)
- Semaglutide impurity 204 (CAS CATO-C4X-2226204)
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