Parecoxib Impurity 15 CAS 386273-25-2
| CAS No. | 386273-25-2 |
| Molecular Formula | C16H14N2O3S |
| Molecular Weight | 314.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Parecoxib Impurity 15 (CAS 386273-25-2, C16H14N2O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Parecoxib Impurity 15 (C16H14N2O3S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H14N2O3S |
| Molecular Weight | 314.36 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Parecoxib Standards
- Parecoxib Impurity 2 (CAS 181695-72-7)
- Parecoxib Impurity 3 (CAS CATO-C4X-15913)
- Parecoxib Impurity 32 (CAS 181696-12-8)
- Parecoxib Impurity 47 (CAS 181695-84-1)
- Parecoxib Impurity 51 (CAS 2304623-35-4)
- Parecoxib Impurity 52 (CAS 2304623-37-6)
- Parecoxib Impurity 6 (CAS CATO-C4X-15916)
- Parecoxib sodium Impurity 9 (CAS 1373038-56-2)
Recommended Standards
- Febuxostat Impurity 110 (CAS 1346238-12-7)
- Sildenafil Impurity 77 (CAS CATO-C4X-112877)
- Sildenafil Impurity 69 (CAS CATO-C4X-112869)
- Sildenafil Impurity 299 (CAS CATO-C4X-1128299)
- Cefuroxime Impurity 61 (CAS CATO-C4X-124561)
- Moxifloxacin Impurity 192 (CAS CATO-C4X-1074192)
- Thioctic acid Impurity 12 (CAS CATO-C4X-152612)
- 3,6-dichloropyridazine-4-carbonyl chloride (CAS 6531-08-4)
- (2-Fluoro-4-(phenylcarbamoyl)phenyl)boronic acid (CAS 874289-24-4)
- 7-bromo-3-chloro-pyrido[2,3-b]pyrazine (CAS 1240594-95-9)
- 5-(Methylsulfanyl)-4-phenyl-1,2,3-thiadiazole (CAS 338408-73-4)
- 2-Hydroxy-3-(trifluoromethyl)pyridine-4-methanol (CAS 1227576-44-4)
- 3-(5-(tert-Butyl)furan-2-yl)-6-iodoisobenzofuran-1(3H)-one (CAS 888498-14-4)
- Semaglutide impurity 65 (CAS CATO-C4X-222665)
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