(4Z)-4-[(4-Methylphenyl)methylidene]-1,3-diphenyl-4,5-dihydro-1H-pyrazol-5-one CAS 39143-16-3

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (4Z)-4-[(4-Methylphenyl)methylidene]-1,3-diphenyl-4,5-dihydro-1H-pyrazol-5-one.

(4Z)-4-[(4-Methylphenyl)methylidene]-1,3-diphenyl-4,5-dihydro-1H-pyrazol-5-one (CAS 39143-16-3), molecular formula C23H18N2O and molecular weight 338.40 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of (4Z)-4-[(4-Methylphenyl)methylidene]-1,3-diphenyl-4,5-dihydro-1H-pyrazol-5-one (C23H18N2O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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