1-((Chloromethyl)sulfonyl)-4-methylpiperazine CAS 3967-02-0
| CAS No. | 3967-02-0 |
| Molecular Formula | C6H13ClN2O2S |
| Molecular Weight | 212.70 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-((Chloromethyl)sulfonyl)-4-methylpiperazine (CAS 3967-02-0) is a high-purity analytical reference standard with the molecular formula C6H13ClN2O2S and a molecular weight of 212.70 g/mol.
The molecular framework of 1-((Chloromethyl)sulfonyl)-4-methylpiperazine (C6H13ClN2O2S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-((Chloromethyl)sulfonyl)-4-methylpiperazine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H13ClN2O2S |
| Molecular Weight | 212.70 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
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Recommended Standards
- (R)-1-(6-Chlorobenzo[d]thiazol-2-yl)ethanamine (CAS 177407-13-5)
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- 2-Propenoic acid, polymer with 2-propenenitrile, sodium salt, sodium bisulfite-terminated (CAS 68479-10-7)
- Berberine Impurity 30 (CAS 2648606-63-5)
- 1-Bromo-3,5-dimethoxy-4-fluorobenzene (CAS 204654-94-4)
- 1-(7-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-indol-3-yl)-2,2-dimethylpropan-1-one (CAS 2390149-36-5)
- Semaglutide Impurity 11 (CAS CATO-C4X-222611)
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